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Inhalt
innate Immunity and Tolerance
Macrophages are most abundant, highly diverse and plastic cells of the innate immune systems present in almost all tissues and organs. Macrophage are responsible for the immunological control of healthy tissues development and turn over, initiation of acute inflammatory defense reactions, resolution of inflammation and healing. Pathological programming of macrophages leads to cancer progression, cardio-metabolic disorders and rejection of implanted materials.
The aims of our research include 1) identification of transcriptional and epigenetic mechanism of macrophage programming in sterile inflammation; 2) identification of new macrophage biomarkers indicative for detrimental reaction to implant materials and chemotherapy; 3) to identify new targets for macrophage therapeutic programming. In cancer and implant intolerance we analyse biomarker and therapeutic value of chitinase-like proteins that modulate infiltration of immune cells and angiogenesis. In diabetes we specifically focus on the transcriptional and epigenetic mechanism induced in macrophages by hyperglycemia.
Publications
Yin S, Wang N, Riabov V, Mossel DM, Larionova I, Schledzewski K, Trofimova O, Sevastyanova T, Zajakina A, Schmuttermaier C, Gratchev A , Flatley A , Kremmer E , Zavyalova M, Cherdyntseva N , Simon-Keller K , Marx A , Klüter H , Goerdt S , Kzhyshkowska J. SI-CLP Inhibits the Growth of Mouse Mammary Adenocarcinoma by Preventing Recruitment of Tumor-Associated Macrophages. Int J Cancer, 146 (5), 1396-1408. 2020 Mar 1. DOI: 10.1002/ijc.3268
Liu T, Larionova I, Litviakov N, Riabov V, Zavyalova M, Tsyganov M, Buldakov M, Song B, Moganti K, Kazantseva P, Slonimskaya E, Kremmer E, Flatley A, Klüter H, Cherdyntseva N, Kzhyshkowska J. Tumor-associated Macrophages in Human Breast Cancer Produce New Monocyte Attracting and Pro-Angiogenic Factor YKL-39 Indicative for Increased Metastasis After Neoadjuvant Chemotherapy. Oncoimmunology, 7 (6), e1436922, 2018 Mar 13. DOI: 10.1080/2162402X.2018.1436922
Riabov V, Salazar F , Htwe S , Gudima A , Schmuttermaier C , Barthes J, Knopf-Marques H, Klüter H, Ghaemmaghami AM, Vrana NE , Kzhyshkowska J. Generation of Anti-Inflammatory Macrophages for Implants and Regenerative Medicine Using Self-Standing Release Systems With a Phenotype-Fixing Cytokine Cocktail Formulation. Acta Biomater, 53, 389-398 2017 Apr 15. DOI: 10.1016/j.actbio.2017.01.071
Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C , Schönhaber H, Weiss C, Fields A, Simon-Keller K, Pfister F, Berlit S, Marx A, Arnold B, Goerdt S, Kzhyshkowska J. Stabilin-1 Is Expressed in Human Breast Cancer and Supports Tumor Growth in Mammary Adenocarcinoma Mouse Model. Oncotarget , 7 (21), 31097-110 2016 May 24. DOI: 10.18632/oncotarget.8857
Kzhyshkowska J, Gudima A, Riabov V, Dollinger C, Lavalle P, Vrana NE. Macrophage Responses to Implants: Prospects for Personalized Medicine. J Leukoc Biol, 98 (6), 953-62 Dec 2015. DOI: 10.1189/jlb.5VMR0415-166R
Kontextspalte
Contact
Prof. (apl.) Dr. rer. nat. Julia Kzhyshkowska
Institut für
Transfusionsmedizin
und Immunologie
Friedrich-Ebert-Straße 107
68167 Mannheim
Phone +49 621 383-9723
julia.kzhyshkowska@medma.uni-heidelberg.de