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Research articles of the Principal Investigators since 2003

2017

Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG. Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. EMBO Mol Med, pii: e201607222, 2017.

Manavski Y, Abel T, Hu J, Kleinlützum D, Buchholz CJ, Belz C, Augustin HG, Boon RA, Dimmeler S. Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A. Proc Natl Acad Sci USA, pii: 201613392, 2017.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel MJ, Ehlting C, Bode JG, Mueller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin HG, Sánchez A, Dooley S, Ten Dijke P. BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut, pii: gutjnl-2016-313314, 2017.

Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG, Ruhrberg C. VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. J Exp Med, 214: 1049-1064, 2017.

Géraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG , Schledzewski K, Goerdt S. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest, 127: 1099-1114, 2017.

Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG. Endosialin promotes atherosclerosis through phenotypic remodeling of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, 37: 495-505, 2017.

Harrill AH, Moggs JG, Adkins KK, Augustin HG, Johnson RC, Leach MW. A synopsis of the "Influence of Epigenetics, Genetics, and Immunology" at the 35th Annual Society of Toxicologic Pathology Symposium. Toxicol Pathol. 45: 114-118, 2017.

2016

Park JS, Kim IK, Han S, Park I, Kim C, Bae J, Oh SJ, Lee S, Kim JH, Woo DC, He Y, Augustin HG, Kim I, Lee D, Koh GY. Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment. Cancer Cell. 30:953-967, 2016.

Sharma KR, Heckler K, Stoll SJ, Hillebrands JL, Kynast K, Herpel E, Porubsky S, Elger M, Hadaschik B, Bieback K, Hammes HP, Nawroth PP, Kroll J. ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Sci Rep. 6:37172, 2016.

Viski C, König C, Kijewska M, Mogler C, Isacke CM, Augustin HG: Endosialin-Expressing Pericytes Promote Metastatic Dissemination. Cancer Res. 76:5313-25, 2016.

Van Hengel, J, Van den Broeke C, Libbrecht L, Hofmann I, van Roy F: Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis. Eur J Cell Biol. 95, 574-584, 2016.

Rathnakumar K, Savant S, Giri H, Ghosh A, Fisslthaler B, Fleming I, Ram U, Bera AK, Augustin HG, Dixit M: Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability. J Thromb Haemost. 14:1655-67, 2016.

Tenhagen M, Klarenbeek S, Schakmann RCJ, Braumuller TM, Hofmann I, van der Groep P, Jonkers J, van der Wall E, Derksen PWB: p120-catenin is critical fort he development of invasive lobular carcinoma in mice. J Mammary Gland Biol Neoplasia. DOI:10.1007/s10911-016-9358-3 [Epub ahead of print], 2016.

Augustin HG: Commentary on Folkman: "How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?". Cancer Res. 76:2854-6, 2016.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL: Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression. Am J Pathol. 186:1874-89, 2016.

Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim YI, Kim P, Kim I, Koh GY: Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 8:335ra55, 2016.

Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Gaida MM, Buchler MW, Strobel O, Hackert T, Giese NA, Augustin HG, Hoheisel JD: Early epigenetic down-regulation of microRNA-192 expression promotes pancreatic cancer progression. Cancer Res May 23. pii: canres.0390.2015. [Epub ahead of print], 2016.

Augustin HG: Commentary on Folkman: “How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?” Cancer Res May 15, 2016 76; 2854. doi: 10.1158/0008-5472.CAN-16-1123, 2016.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL.: Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression. Am J Pathol. 186:1874-89, 2016.

Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG: Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation. Sci Signal 26;9(425):ra42. doi: 10.1126/scisignal.aad3812, 2016.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca2+/NFAT Signaling. Dev Cell 36:79-93, 2016.

2015

Yang C, Fischer-Kešo R, Schlechter T, Ströbel P, Marx A, Hofmann I: Plakophilin 1-deficient cells up-regulate SPOCK1: implications for prostate cancer progression. Tumor Biol. 36, 9567-9577, 2015.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA: MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J Mol Cell Cardiol. 88:111-9, 2015.

Simons M, Alitalo K, Annex B, Augustin HG, Beam C, Berk B, Byzova T, Carmeliet P, Cooke J, Davis G, Eichmann A, Iruela-Arispe L, Keshet E, Sinusas A, Ruhrberg C, Woo J, Dimmeler S: AHA Guidelines: Animal models for measuring angiogenesis and tissue vascularization. Circulation Res, 116:e99-132, 2015.

Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R: A functional role for VEGFR1 expressed in peripheral sensory neurons in cancer pain. Cancer Cell, 27:780-96, 2015.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep12:1761-73, 2015.

Korn C, Augustin HG: Mechanisms of Vessel Pruning and Regression. Dev Cell, 34:5-17, 2015.

Kiesow K, Bennewitz K, Miranda LG, Stoll SJ, Hartenstein B, Angel P, Kroll J* and Schorpp-Kistner M*:
Junb controls lymphatic vascular development in zebrafish via miR-182. Scientific Reports 5, 15007 EP , 2015. *joint last authorship

Klose R, Berger C, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A: Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis. Cardiovasc Res in press, 2015.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T: Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. Apr 9. pii: fj.14-267633. [Epub ahead of print] 2015.

Teichert M, Stumpf C, Booken N, Wobser M, Nashan D, Hallermann C, Mogler C, Müller CS, Becker JC, Moritz RK, Andrulis M, Nicolay JP, Goerdt S, Thomas M, Klemke CD, Augustin HG, Felcht M: Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis. Exp Dermatol. in press, 2015.

Mogler C, Wieland M, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG: Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. EMBO Mol Med. 7: 332-8, 2015.

2014

Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26:880-95, 2014.

Fischer-Kešo R, Breuninger S, Hofmann S, Henn M, Röhrig T, Ströbel P, Stoecklin G, Hofmann I: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol Cell Biol. 34:4244-56, 2014.

Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG and Alitalo K: Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev. 28:1592-603, 2014.

Rappe U, Aschoff M, Hotz-Wagenblatt A, Hofmann I: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing. J Biol Chem. , J289:12421-12434, 2014.

Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P: Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall. Virchows Arch. , Jun 13. DOI 10.1007/s00428-014-1606-6, 2014.

Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin HG: An inducible hepatocellular carcinoma model for preclinical evaluation of anti-angiogenic therapy in adult mice. Cancer Res., Jun 6. pii: canres.2311.2013, 2014.

Kather JN, Friedrich J, Woik N, Sticht C, Gretz N, Hammes HP, Kroll J: Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP deficient mice. Invest Ophthalmol Vis Sci., Jun 10. pii: IOVS-13-13619,2014.

Korn C, Scholz B, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I: Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development. 141:1757-66, 2014.

Woik N, Dietz CT, Schäker K, Kroll J: Kelch-like ECT2 interacting protein KLEIP regulates late stage pulmonary maturation via Hif-2α. Dis.Model.Mech., 7:683-92, 2014.

Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind JS, Li X, Kroll J, Dimmeler S, Chavakis E: Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Res Cardiol. 109: 404, 2014.

2013


Hollenbach M, Stoll SJ, Jörgens K, Seufferlein T, Kroll J: Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1). PLoS One. 8:e68033, 2013.

Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 24;343(6169):416-9., 2013.

Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, Herting F, Yu S, The HH, Martarello L, Gassner C, Stubenrauch KG, Munro K, Augustin HG, Thomas M.: Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy. Clin Cancer Res., 19:6730-40, 2013.

Yang C, Ströbel P, Marx A, Hofmann I: Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis. Virchows Arch., 463:379-90, 2013.

Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG , Fischer A: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res., 113:1206-18, 2013.

Benest AV, Kruse K, Savant S, Thomas M, Laib AM, Loos EK, Fiedler U, Augustin HG: Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS One., 8:e70459, 2013.

Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hämmerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG , Goerdt S: Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver Int., 33:1428-40, 2013.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG , Fässler R, Deutsch U, Kupatt C: Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest., pii: 66549. 2013.

Fleming TH, Theilen TM, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M and Nawroth PP: Aging-dependent reduction in Glyoxalase-I delays wound healing. Gerontology, in press 2013.

Stoll SJ, Bartsch S and Kroll J: HOXC9 Regulates Formation of Parachordal Lymphangioplasts and the Thoracic Duct in Zebrafish via Stabilin 2. PLoS One, 2013;8(3):e58311. doi: 10.1371/journal.pone.0058311. Epub 2013 Mar 6.

Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE: Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res 73:1649-57, 2013.

Fischer S, Gesierich S, Griemert B, Schänzer A, Acker T, Augustin HG, Olsson AK, Preissner KT: Extracellular RNA liberates tumor necrosis factor-a to promote tumor cell trafficking and progression. Cancer Res 73:5080-9, 2013.

Im JH, Tapmeier T, Balathasan L, Gal A, Yameen S, Hill S, Smart S, Noterdaeme O, Kelly M, Brady M, Fu W, Kruse K, Bernhard E, Augustin HG, Muschel RJ: G‐CSF rescues tumor growth and neo‐angiogenesis during liver metastasis under host angiopoietin‐2 deficiency. Int J Cancer 132:315‐26, 2013.

Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, Zelent A, Rössig L, Zeiher AM, Augustin HG, Urbich C, Dimmeler S: Histone Deacetylase 9 Promotes Angiogenesis by Targeting the Antiangiogenic MicroRNA‐17‐92 Cluster in Endothelial Cells. Arterioscler Thromb Vasc Biol 33:533‐43, 2013.

2012

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M: Angiopoietin-1 mediates inhibition of hypertension-induced release of Angiopoietin-2 from endothelial cells. Cardiovasc. Res., 94: 510-8, 2012.

Géraud C, Evdokimov K, Straub BK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Augustin HG, Schirmacher P, Peitsch WK, Goerdt S: Unique cell type-specific junctional complexes in fenestrated endothelium of human and rat liver sinusoids. Plos One, 7(4):e34206, 2012.

Kather JN and Kroll J. Rho guanine exchange factors in blood vessels: fine-tuners of angiogenesis and vascular function. Exp Cell Res. 2012, in press.

Medvetz D, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP: Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion. PLoS One. 7(11): e47842, 2012

Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DYR, Srivastava D. miR-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting VEGF signaling. Circ Res. 111:1421‐33, 2012.

Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest, 1;122(6):1991-2005, 2012.

Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A: No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One 7:e53074, 2012.

Bieback K, Hecker A, Schlechter T, Hofmann I, Brousos N, Redmer, T, Besser D, Klüter H, Müller AM, Becker M: Replicative aging and differentiation potential of human adipose tissue-derived mesenchymal stromal cells expanded in pooled human or fetal bovine serum. Cytotherapy 14:570-83, 2012.

Korn C, Augustin HG. Born to Die: Blood Vessel Regression Research Coming of Age. Circulation, Jun 1 [Epub ahead of print], 2012.

Stoll SJ, and Kroll J. HOXC9: A key regulator of endothelial cell quiescence and vascular morphogenesis. Trends in Cardiovascular Medicine, 22(1):7-11, 2012.

Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomäki H, Teichert M, Huang H, Edqvist PH, Kraus T, Augustin HG, Olofsson T, Larsson E, Söderberg O, Molema G, Pontén F, Georgii-Hemming P, Alafuzoff I, Dimberg A: Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol 228:378-90, 2012

Kurley SJ, Bierie B, Carnahan RH, Lobdell NA, Davis MA, Hofmann I, Moses HL, Muller WJ, Reynolds AB: P120-catenin is essential for terminal end bud function and mammary morphogenesis. Development 139:1754-1764, 2012

Hahn N, Dietz CT, Kühl S, Voßmerbäumer U, and Kroll J. KLEIP deficiency in mice causes progressive corneal neovascular dystrophy. Investigative Ophthalmology & Visual Science, 53(6):3260-8, 2012.

Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, and Wieland T. Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium. Cellular Signalling , 24: 1261-1269, 2012.

Munoz WA, Kloc M, Cho K, Lee M, Hofmann I, Sater A, Vleminckx K, McCrea PD. Plakophilin-3 is required for late embryonic amphibian development exhibiting roles in ectodermal and neural tissues. PLoS One. 7(3):e34342, 2012.

Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon R, Bonauer A, Döbele C, Böckel JN, Hergenreider E, Zeiher AM, Kroll J, Fleming I, and Dimmeler S. MicroRNA-27a/b controls repulsion and angiogenesis by targeting semaphorin 6A in endothelial cells. Blood, 119:1607-1616, 2012.

Jörgens K, Hillebrands JL, Hammes HP, and Kroll J. Zebrafish: A model for understanding diabetic complications. Exp Clin Endocrinol Diabetes, 20(4):186-7, 2012.

2011

Jörgens K, Schäker K, and Kroll J. Der Modellorganismus Zebrafisch in der biomedizinischen Grundlagenforschung: Anwendungen und Perspektiven in der vaskulären Biologie und Medizin. Dtsch Med Wochenschr, 136: 1865-1868, 2011.

Marchiano D, Brakeman PR, Lee C-Z, Spivak N, Eastburn DJ, Beuadoin GM, Hofmann I, Mostov KE, Reichardt LF:: p120 regulates epithelial tubulogenisis. Development; 138: 2099-2109, 2011.

Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, and Urbich C. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J, 30: 4142– 4156, 2011.

Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, Nasarre P, Hofer-Warbinek R, Bilban M, Augustin HG, Hofer E: The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood, 117: 2735-44, 2011.

Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res., April 14, 2011.

Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG: Differential endothelial transcriptomics identifies Semaphorin 3G as a vascular class 3 semaphorin. Arterioscler Thromb Vasc Biol., 31: 151-9, 2011.

2010

Héroult M, Schaffner F, Pfaff D, Prahst C, Kirmse R, Kutschera S, Riedel M, Ludwig T, Vajkoczy P, Graeser R, Augustin HG: EphB4 promotes site-specific metastatic tumor cell dissemination by interacting with endothelial cell expressed ephrinB2. Mol Cancer Res. 8:1297-3, 2010.

Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A. Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A. Jul 13;107(28):12640-5, 2010.

Walter B, Krebs U, Berger I, Hofmann I: Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules. Histochem. Cell Biol. 133:69-83, 2010.

Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A. Integrin Cytoplasmic Domain-Associated Protein-1 Attenuates Sprouting Angiogenesis. Circ Res. Sep 3;107(5):592-601, 2010.

Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I. Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: Implications for diagnosis and tumor progression. Am. J. Pathol. 176:2509-2519, 2010.

Goede V, Coutelle O, Neuneier J, Reinacher-Schick A, Schnell R, Koslowsky TC, Weihrauch MR, Cremer B, Kashkar H, Odenthal M, Augustin HG, Schmiegel W, Hallek M, Hacker UT: Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy. Br J Cancer; 103:1407-14, 2010

Thomas M, Felcht M, Kruse K, Kretschmer S, Deppermann C, Biesdorf A, Rohr K, Benest AV, Fiedler U, Augustin HG. Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem. Jul 30;285(31):23842-9, 2010.

Epting D*, Wendik B*, Bennewitz K, Dietz CT, Driever W, and Kroll J. The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish. Circ Res. Jul 9;107(1):45-55, 2010.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M: Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 120:2307-18, 2010.

2009

Kroll J*, Epting D*, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, and Augustin HG. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularisation and sprouting angiogenesis. Am J Physiol Heart Circ Physiol, 296: H893-H899, 2009.

Anna M Laib, Arne Bartol, Abdullah Alajati, Thomas Korff, Holger Weber & Hellmut G Augustin. Spheroid-based human endothelial cell microvessel formation in vivo. Nature Protocols, 4:1202 - 1215 , 2009.

Walter B, Berger I, Hofmann I. The proteins ARVCF and p0071 in renal cell carcinomas and their potential use in the diagnosis of renal tumors. Histopathol., 55:761-764, 2009.

Tremmel M, Matzke A, Albrecht I, Laib AM, Olaku V, Ballmer-Hofer K, Christofori G, Héroult M, Augustin HG, Ponta H, Orian-Rousseau V: A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis. Blood, 114:5236-44, 2009.

Hofmann I, Schlechter T, Kuhn C, Hergt M, Franke WW: Protein p0071, an armadillo plaque protein that characterizes a specific subtype of adherens junctions. J. Cell Sci. 122:21-24, 2009.

Nasarre P, Thomas M, Kruse K, Helfrich I, Wolter V, Deppermann C, Schadendorf D, Thurston G, Fiedler U, Augustin HG: Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res, 69:1324-33, 2009.

Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV: FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol. 185:439-57, 2009.

Moll R, Sievers E, Hämmerling B, Schmidt A, Barth M, Kuhn C, Grund C, Hofmann I, Franke WW: Endothelila and virgultar cell formations in the mammalian lymph node sinus by a special kind of junction (complexus adhaerens). Cell Tissue Res. 335:109-141, 2009.

Scheidegger F, Ellner Y, Guye P, Rhomberg TA, Weber H, Augustin HG, Dehio C: Distinct activities of Bartonella henselae type IV secretion effector proteins modulate capillary-like sprout formation. Cell Microbiol. 11:1088-101, 2009.

Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL: Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest. 119:2359-65, 2009.

2008

Prahst C, Héroult M, Lanahan AA, Uziel N, Kessler O, Shraga-Heled N, Simons M, Neufeld G, and Augustin HG: Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1. J. Biol. Chem. Vol. 283, Issue 37, 25110-25114, 2008.

Becker R, Lenter MC, Vollkommer T, Boos AM, Pfaff D, Augustin HG and Christian S: Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K. The FASEB Journal Aug;22(8):3059-67, 2008.

Hofmann I, Kuhn C, Franke WW: Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell-type marker. Cell Tissue Res. 334:381-399, 2008.

Thiel L, Diederich S, Erbar S, Pfaff D, Augustin HG, Maisner A: Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail. Virol J. 5:163, 2008.

Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF & Kalluri R: Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 453, 1117-1121, 2008.

Pfaff D, Heroult M, Riedel N, Reiss Y, Kirmse R, Ludwig L, Korff T, Hecker M, Augustin HG: Involvement of endothelial ephrinB2 in adhesion and transmigration of EphB expressing monocytes. J Cell Sci, 121:3842-50, 2008.

Walter B, Schlechter T, Hergt M, Berger I, Hofmann I: Differential expression pattern of Protein ARVCF in nephron segments of human and mouse kidney. Histochem. Cell Biol. 130:943-956, 2008.

Korff T, Braun J, Pfaff D, Augustin HG, and Hecker M: Role of ephrinB2 expression in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment. Blood Vol. 112, No. 1, pp. 73-81, 2008.

Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M & Augustin HG: Spheroid-based engineering of a human vasculature in mice. Nat Methods. 5(5):439-45, 2008.

Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt B: Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47:1018 - 1031, 2008.

Christian S, Winkler R, Helfrich I, Boos AM, Besemfelder E, Schadendorf D, Augustin HG: Endosialin (tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol. 172(2):486-94, 2008.

Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morawietz H: Flow-dependent regulation of Angiopoietin-2. J Cell. Physiol. 214(2):491-503, 2008.

2007

Nacak TG, Alajati A, Leptien K, Fulda C, Weber H, Miki T, Czeplich FS, Waltenberger J, Wieland T, Augustin HG, Kroll J.: The BTB-kelch protein KLEIP controls endothelial migration and sprouting angiogeneiss. Circ. Res. 100: 1155-1163, 2007.

Franke WW, Schumacher H, Borrmann CM, Grund C, Winter-Simanowski S, Schlechter T, Pieperhoff S, Hofmann I.: The area composita of adhering junctions connecting heart muscle cells of vertebrates. III. Assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture. Eur. J. Cell Biol. 86:127-142, 2007.

Shraga-Heled N, Kessler O, Prahst C, Kroll J, Augustin HG, Neufeld G.: Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor. FASEB J. 21: 915-926, 2007.

Potiron VA, Sharma G, Nasarre P, Clarhaut JA, Augustin HG, Gemmill RM, Roche J, Drabkin HA: Semaphorin SEMA3F affects multiple signalling patways in lung cancer cells. Cancer Res, 67: 8708-8715, 2007.

2006

Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner K, Vajkoczy P, Augustin HG.: Angiopoietin-2 sensitizes endothelial cells to TNF and plays a crucial role in the induction of inflammation. Nat. Med. 12:235-239, 2006

Peitsch WK, Bulkescher J, Spring H, Hofmann I, Goerdt S, Franke WW. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin enriched zone. Exp. Cell Res. 312:2605-2618, 2006

Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG.: Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context dependently with CD31. Arterioscl. Thromb. Vasc. Biol. 26: 468-474, 2006

Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett MS, Bates DO, Christofori G, Augustin HG.: The sialomucin CD34 is a marker of tumor-associated lymphatic endothelial cells in human tumors. Am. J. Pathol. 168:1045-1053, 2006

Borrmann C, Grund C, Kuhn C, Hofmann I, Pieperhoff S, Franke WW.: The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules. Eur. J. Cell Biol. 85:469-485, 2006

Nacak TG, Leptien K, Fellner D, Augustin HG, Kroll J.: The BTB-kelch protein LZTR-1 is a novel trans-Golgi network protein and is degraded upon induction of apoptosis. J. Biol. Chem. 281: 5065-5071, 2006

Hofmann I , Casella M, Schnölzer M, Schlechter T, Spring H, Franke WW.: Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol. Biol. Cell. 17:1388-1398, 2006

Krneta J, Kroll J, Alves F, Prahst C, Sananbenesi F, Dullin C, Kimmina S, Phillips DJ, Augustin HG.: Dissociation of angiogenesis and tumorigenesis in activin and follistatin expressing tumors. Cancer Res. 66: 5685-5695, 2006

Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T.: The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood 107: 2720-2727, 2006

2005

Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG.: The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J. Cell Sci. 118:771-780, 2005

Saharinen P, Kerkela K, Ekman N, Marron M, Brindle N, Lee GM, Augustin H, Koh GY, Alitalo K.: Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J. Cell Biol. 169:239-243, 2005

Müller SM, Terszowski G, Blum C, Haller C, Anquez V, Kuschert S, Carmeliet P, Augustin HG, Rodewald HR.: Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc Natl Acad Sci USA 102: 10597-10592, 2005

Peitsch W K, Hofmann I, Bulkescher J, Hergt M, Spring H, Bleyl U, Goerdt S, Franke WW.: Drebrin, an actin-binding, cell type characteristic protein: induction and localization in epithelial skin tumors and cultured keratinocytes. J. Invest. Dermatol. 125:761-744, 2005

ADDIN EN.REFLIST Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, Sato TN: The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol. Cell. Biol. 25: 8531-8540, 2005

2004

Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt JM, Kriz W, Thurston G, Augustin HG.: The Tie-2 ligand Angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103: 4150-4156, 2004

Martiny-Baron G, Korff T, Schaffner F, Esser N, Eggstein S, Marmé D, Augustin HG.: Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia 6: 248-257, 2004

Hegen A, Koidl S, Weindel K, Marme D, Augustin HG, Fiedler U.: Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol 24: 1803-1809, 2004

Krauss T, Pauer U, Augustin HG.: Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia. Hypertens. Pregnancy 22: 101-111, 2004

Goettsch W, Augustin HG, Morawietz H. Down-regulation of endothelial EphrinB2 expression by laminar shear stress. Endothelium 11:259-265, 2004

Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G.: Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model. Biochem Biophys Res Commun  322: 684-692, 2004

Wenger A, Stahl A, Weber H, Finkenzeller G, Augustin HG, Stark GB, Kneser U.: Modulation of in vitro angiogenesis in a three-dimensional spheroidal co-culture model for bone tissue engineering. Tissue Eng. 10: 1536-1547, 2004

Korff T, Krauss T, Augustin HG.: Three-dimensional spheroidal culture of cytotrophoblast cells mimics the phenotype and differentiation of cytotrophoblasts from normal and preeclamptic pregnancies. Exp. Cell Res. 297: 415-423, 2004

2003

Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marme D, Augustin HG.: Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first IgG-like loop and the EGF-like repeats. J. Biol. Chem. 278: 1721-1727, 2003

Füller T, Korff T, Killian A, Dandekar G, Augustin HG.: Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J. Cell Sci. 116: 2461-70, 2003

Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Jeltsch M, Augustin HG, Alitalo K.: ntrinsic versus microenviromental regulation of lymphatic endothelial cell phenotype and function. FASEB J. 17: 2006-2013, 2003

Scheuffler KM, Drevs A, Von Velthoven V, Augustin HG, Reusch P, Klisch J, Zentner J, Marme D. Significance of VEGF, sFlt-1, and sTie-2 in plasma, serum, and CSF during cerebral ischemia. J. Cereb. Blood Flow Metab. 23: 99-110, 2003

Piossek C, Thierauch KH, Schneider-Mergener J, Volkmer-Engert R, Bachmann MF, Korff T, Augustin HG, Germeroth L.: Potent inhibition of angiogenesis by D,L-peptides derived from vascular endothelial growth factor receptor 2. Thromb Haemost. 90: 501-510, 2003

Peitsch WK, Hofmann I, Endlich N, Prätzel S, Kuhn C, Spring H, Gröne H-J, Kriz W, Franke WW.: Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. J. Am. Soc. Nephrol. 9: 14:1452-1463, 2003

Autiero M, Waltenberger J, Communi D, Kranz A, Moons L, Lambrechts D, Kroll J, Plaisance S, De Mol M, Bono F, Kliche S, Fellbrich G, Ballmer-Hofer K, Maglione D, Mayr-Beyrle U, Dewerchin M, Dombrowski S, Stanimirovic D, Van Hummelen P, Dehio C, Hicklin DJ, Persico G, Herbert JM, Shibuya M, Collen D, Conway EM, Carmeliet P.: Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1. Nat. Med. 9: 936-943, 2003

Kroll J, Cobo P, Sato TN. Versatile inducible activation system of Akt/PKB signaling pathway in mice. Genesis 35: 160-163, 2003.

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