Publications & Theses

2024

Gellert J, Agardy DA, Kumar S, Kourtesakis A, Boschert T, Jähne K, Breckwoldt MO, Bunse L, Wick W, Davies MA, Platten M, Bunse T. Tumoral Interferon Beta Induces an Immune-Stimulatory Phenotype in Tumor-Associated Macrophages in Melanoma Brain Metastases. Cancer Res Commun. 2024 Aug 1;4(8):2189-2202. doi: 10.1158/2767-9764.CRC-24-0024

Grube M, Dimmler A, Schmaus A, Saup R, Wagner T, Garvalov BK, Sleeman JP, Thiele W. Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice in vivo. Clin Exp Metastasis. 2024 Jun;41(3):251-266. doi: 10.1007/s10585-023-10249-z. Epub 2023 Dec 9

Hering M*, Madi A, Sandhoff R, Ma S, Wu J, Mieg A, Richter K, Mohr K, Knabe N, Stichling D, Poschet G, Bestvater F, Frank L, Utikal J, Umansky V, Cui G*. Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma. Nat Commun. 2024 Jul 18;15(1):6067. doi: 10.1038/s41467-024-50341-w

Hofman T, Ng SW, Garcés-Lázaro I, Heigwer F, Boutros M, Cerwenka A. IFNγ mediates the resistance of tumor cells to distinct NK cell subsets. J Immunother Cancer. 2024 Jul 1;12(7):e009410. doi: 10.1136/jitc-2024-009410

Kilian M, Friedrich MJ, Lu KH, Vonhören D, Jansky S, Michel J, Keib A, Stange S, Hackert N, Kehl N, Hahn M, Habel A, Jung S, Jähne K, Sahm F, Betge J, Cerwenka A, Westermann F, Dreger P, Raab MS, Meindl-Beinker NM, Ebert M, Bunse L, Müller-Tidow C, Schmitt M, Platten M. The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance. Sci Immunol. 2024 May 3;9(95):eadj7970. doi: 10.1126/sciimmunol.adj7970. Epub 2024 May 3

Krämer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. NLGN4X TCR transgenic T cells to treat gliomas. Neuro Oncol. 2024 Feb 2;26(2):266-278. doi: 10.1093/neuonc/noad172

Lasser SA, Ozbay Kurt FG, Arkhypov I, Utikal J, Umansky V. Myeloid-derived suppressor cells in cancer and cancer therapy. Nat Rev Clin Oncol. 2024 Feb;21(2):147-164. doi: 10.1038/s41571-023-00846-y. Epub 2024 Jan 8. (Review)

Lasser SA, Ozbay Kurt FG, Fritz L, Gutzeit N, De La Torre C, Altevogt P, Utikal J, Umansky V. Generation of Myeloid-Derived Suppressor Cells Mediated by MicroRNA-125a-5p in Melanoma. Int J Mol Sci. 2024 Jun 18;25(12):6693. doi: 10.3390/ijms25126693

Ma S*, Sandhoff R, Luo X, Shang F, Li Z, Wu J, Schwarz F, Ming Y, Madi A, Weisshaar N, Mieg A, Mohr K, ten Bosch N, Li Z, Hering M, Poschet G, Buettner M, Rodewald HR, Wang X*, Gao P*, Cui G*. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Sci Immunol. 2024 Apr 19;9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. Epub 2024 Apr 19

Messmer JM, Thommek C, Piechutta M, Venkataramani V, Wehner R, Westphal D, Schubert M, Mayer CD, Effern M, Berghoff AS, Hinze D, Helfrich I, Schadendorf D, Wick W, Hölzel M, Karreman MA*, Winkler F*. T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels. Immunity. 2024 Sep 28:S1074-7613(24)00447-3. doi: 10.1016/j.immuni.2024.09.003. Online ahead of print

Özbay Kurt FG, Cicortas BA, Balzasch BM, de la Torre C, Ast V, Tavukcuoglu E, Ak C, Wohlfeil SA, Cerwenka A, Utikal J, Umansky V. S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling. J Immunother Cancer. 2024 Sep 11;12(9):e009552. doi: 10.1136/jitc-2024-009552

Roesler J, Spitzer D, Jia X, Aasen SN, Sommer K, Roller B, Olshausen N, Hebach NR, Albinger N, Ullrich E, Zhu L, Wang F, Macas J, Forster MT, Steinbach JP, Sevenich L, Devraj K, Thorsen F, Karreman MA, Plate KH, Reiss Y, Harter PN.. Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis. Neuro Oncol. 2024 Nov 4;26(11):2084-2099. doi: 10.1093/neuonc/noae094

Schlieper-Scherf S, Hebach N, Hausmann D, Azorín DD, Hoffmann DC, Horschitz S, Maier E, Koch P, Karreman MA, Etminan N, Ratliff M. Disrupting glioblastoma networks with tumor treating fields (TTFields) in in vitro models. J. Neurooncol. 2024 Oct;170(1):139-151. doi: 10.1007/s11060-024-04786-0. Epub 2024 Aug 1

Streibel Y, Breckwoldt MO, Hunger J, Pan C, Fischer M, Turco V, Boztepe B, Fels-Palesandro H, Scheck JG, Sturm V, Karimian-Jazi K, Agardy DA, Annio G, Mustapha R, Soni SS, Alasa A, Weidenfeld I, Rodell CB, Wick W, Heiland S, Winkler F, Platten M, Bendszus M, Sinkus R, Schregel K. Tumor biomechanics as a novel imaging biomarker to assess response to immunotherapy in a murine glioma model. Sci Rep. 2024 Jul 6;14(1):15613. doi: 10.1038/s41598-024-66519-7

Tauch S, Kast B, Lohr S, Kemm L, Sator-Schmitt M, Gengenbacher N, Augustin HG, Angel P. CAF Specific Expression of Podoplanin May Be Dispensable for the Malignancy of Malignant Melanoma. Mol Carcinog. 2024 Nov 8. doi: 10.1002/mc.23841. Online ahead of print

Wißfeld J, Hering M, ten Bosch N, Cui G. The immunosuppressive drug cyclosporin A has an immunostimulatory function in CD8+ T cells. Eur J Immunol. 2024 Jul;54(7):e2350825. doi: 10.1002/eji.202350825. Epub 2024 Apr 22

Wohlfeil SA, Olsavszky A, Irkens AL, Häfele V, Dietsch B, Straub N, Goerdt S, Géraud C. Deficiency of Stabilin-1 in the Context of Hepatic Melanoma Metastasis. Cancers (Basel). 2024 Jan 19;16(2):441. doi: 10.3390/cancers16020441

Wiecken M, Machiraju D, Chakraborty S, Mayr EM, Lenoir B, Eurich R, Richter J, Pfarr N, Halama N, Hassel JC. The immune checkpoint LAG-3 is expressed by melanoma cells and correlates with clinical progression of the melanoma. Oncoimmunology. in press

Strobel SB, Machiraju D, Wiecken M, Richter J, Klein JAF, Berger A, Hassel JC. CMV IgG in the blood is not associated with hepatitis but correlates with poor outcomes in immunotherapy treated melanoma patients. Cancer Immunology, Immunotherapy. in press

2023

Dietsch B, Weller C, Sticht C, de la Torre C, Kramer M, Goerdt S, Géraud C, Wohlfeil SA. Hepatic passaging of NRAS-mutant melanoma influences adhesive properties and metastatic pattern. BMC Cancer. 2023 May 13;23(1):436. doi: 10.1186/s12885-023-10912-4

Friedrich M, Hahn M, Michel J, Sankowski R, Kilian M, Kehl N, Günter M, Bunse T, Pusch S, von Deimling A, Wick W, Autenrieth SE, Prinz M, Platten M, Bunse L. Dysfunctional dendritic cells limit antigen-specific T cell response in glioma. Neuro Oncol. 2023 Feb 14;25(2):263-276. doi: 10.1093/neuonc/noac138

Friedrich MJ, Neri P, Kehl N, Michel J, Steiger S, Kilian M, Leblay N, Maity R, Sankowski R, Lee H, Barakat E, Ahn S, Weinhold N, Rippe K, Bunse L, Platten M, Goldschmidt H, Müller-Tidow C, Raab MS, Bahlis NJ. The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients. Cancer Cell. 2023 Apr 10;41(4):711-725.e6. doi: 10.1016/j.ccell.2023.02.008. Epub 2023 Mar 9

Groth C, Maric J, Garcés Lázaro I, Hofman T, Zhang Z, Ni Y, Keller F, Seufert I, Hofmann M, Neumann-Haefelin C, Sticht C, Rippe K, Urban S, Cerwenka A. Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity. Front Immunol. 2023 Dec 8:14:1287367. doi: 10.3389/fimmu.2023.1287367. eCollection 2023

Hausmann D, Hoffmann DC, Venkataramani V, Jung E, Horschitz S, Tetzlaff SK, Jabali A, Hai L, Kessler T, Azoŕin DD, Weil S, Kourtesakis A, Sievers P, Habel A, Breckwoldt MO, Karreman MA, Ratliff M, Messmer JM, Yang Y, Reyhan E, Wendler S, Löb C, Mayer C, Figarella K, Osswald M, Solecki G, Sahm F, Garaschuk O, Kuner T, Koch P, Schlesner M, Wick W, Winkler F. Autonomous rhythmic activity in glioma networks drives brain tumour growth. Nature. 2023 Jan;613(7942):179-186. doi: 10.1038/s41586-022-05520-4. Epub 2022 Dec 14

Hübers C*, Abdul Pari AA*, Grieshober D*, Petkov M, Schmidt A, Messmer T, Heyer CM, Schölch S, Kapel SS, Gengenbacher N, Singhal M, Schieb B, Fricke C, Will R, Remans K, Utikal JS, Reissfelder C, Schlesner M, Hodivala-Dilke KM, Kersten S, Goerdt S, Augustin HG*, Felcht M*. Primary tumor-derived systemic nANGPTL4 inhibits metastasis. J Exp Med. 2023 Jan 2;220(1):e20202595. doi: 10.1084/jem.20202595. Epub 2022 Oct 21

Hunger J, Schregel K, Boztepe B, Agardy DA, Turco V, Karimian-Jazi K, Weidenfeld I, Streibel Y, Fischer M, Sturm V, Santarella-Mellwig R, Kilian M, Jähne K, Sahm K, Wick W, Bunse L, Heiland S, Bunse T, Bendszus M, Platten M, Breckwoldt MO. In vivo nanoparticle-based T cell imaging can predict therapy response towards adoptive T cell therapy in experimental glioma. Theranostics. 2023 Sep 25;13(15):5170-5182. doi: 10.7150/thno.87248. eCollection 2023

Karreman MA, Bauer AT, Solecki G, Berghoff AS, Mayer CD, Frey K, Hebach N, Feinauer MJ, Schieber NL, Tehranian C, Mercier L, Singhal M, Venkataramani V, Schubert MC, Hinze D, Hölzel M, Helfrich I, Schadendorf D, Schneider SW, Westphal D, Augustin HG, Goetz JG, Schwab Y, Wick W, Winkler F. Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization. Cancer Res. 2023 Apr 14;83(8):1299-1314. doi: 10.1158/0008-5472.CAN-22-3964

Leibing T, Riedel A, Xi Y, Adrian M, Krzistetzko J, Kirkamm C, Dormann C, Schledzewski K, Goerdt S, Géraud C. Deficiency for scavenger receptors Stabilin-1 and Stabilin-2 leads to age-dependent renal and hepatic depositions of fasciclin domain proteins TGFBI and Periostin in mice. Aging Cell. 2023 Sep;22(9):e13914. doi: 10.1111/acel.13914. Epub 2023 Jun 25

Lepper A, Bitsch R, Özbay Kurt FG, Arkhypov I, Lasser S, Utikal J, Umansky V. Melanoma patients with immune-related adverse events after immune checkpoint inhibitors are characterized by a distinct immunological phenotype of circulating T cells and M-MDSCs. Oncoimmunology. 2023 Aug 13;12(1):2247303. doi: 10.1080/2162402X.2023.2247303. eCollection 2023

Madi A, Wu J, Ma S, Weisshaar N, Mieg A, Hering M, Ming Y, Zettl F, Mohr K, Ten Bosch N, Schlimbach T, Hertel F, Cui G. Regulatory T cell-derived interleukin-15 promotes the diversity of immunological memory. Eur J Immunol. 2023 Jan;53(1):e2149400. doi: 10.1002/eji.202149400. Epub 2022 Nov 4

Ozbay Kurt FG, Lasser S, Arkhypov I, Utikal J, Umansky V. Enhancing immunotherapy response in melanoma: myeloid-derived suppressor cells as a therapeutic target. J Clin Invest. 2023 Jul 3;133(13):e170762. doi: 10.1172/JCI170762. (Review)

Pereira Sena P, Weber JJ, Bayezit S, Saup R, Incebacak Eltemur RD, Li X, Velic A, Jung J, Macek B, Nguyen HP, Riess O, Schmidt T. Implications of specific lysine residues within ataxin-3 for the molecular pathogenesis of Machado-Joseph disease. Front Mol Neurosci. 2023 May 19:16:1133271. doi: 10.3389/fnmol.2023.1133271. eCollection 2023

Petrova V, Groth C, Bitsch R, Arkhypov I, Simon SCS, Hetjens S, Müller V, Utikal J, Umansky V. Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients. Front Immunol. 2023 Feb 13:14:1065767. doi: 10.3389/fimmu.2023.1065767. eCollection 2023

Popović A, Miihkinen M, Ghimire S, Saup R, Grönloh ML, Ball NJ, Goult BT, Ivaska J, Jacquemet G. Myosin-X recruits lamellipodin to filopodia tips. J Cell Sci. 2023 Mar 1;136(5):jcs260574. doi: 10.1242/jcs.260574. Epub 2023 Mar 2

Preuss SF*, Grieshober D*, Augustin HG. Systemic reprogramming of EC signaling in metastasis and cachexia. Physiology (Bethesda). 2023 Jul 1;38(4):0. doi: 10.1152/physiol.00001.2023. (Review)

Saup R, Nair N, Shen J, Schmaus A, Thiele W, Garvalov BK, Sleeman JP. Increased Circulating Osteopontin Levels Promote Primary Tumour Growth, but Do Not Induce Metastasis in Melanoma. Biomedicines. 2023 Mar 28;11(4):1038. doi: 10.3390/biomedicines11041038

Schmid CD, Olsavszky V, Reinhart M, Weyer V, Trogisch FA, Sticht C, Winkler M, Kürschner SW, Hoffmann J, Ola R, Staniczek T, Heineke J, Straub BK, Mittler J, Schledzewski K, Ten Dijke P, Richter K, Dooley S, Géraud C, Goerdt S, Koch PS. ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver. Hepatology. 2023 Apr 1;77(4):1211-1227. doi: 10.1002/hep.32641. Epub 2022 Jul 17

Schregel K, Heinz L, Hunger J, Pan C, Bode J, Fischer M, Sturm V, Venkataramani V, Karimian-Jazi K, Agardy DA, Streibel Y, Zerelles R, Wick W, Heiland S, Bunse T, Tews B, Platten M, Winkler F, Bendszus M, Breckwoldt MO. A Cellular Ground Truth to Develop MRI Signatures in Glioma Models by Correlative Light Sheet Microscopy and Atlas-Based Coregistration. J Neurosci. 2023 Jul 26;43(30):5574-5587. doi: 10.1523/JNEUROSCI.1470-22.2023. Epub 2023 Jul 10

Simon SCS, Müller V, Utikal JS. Case report: Therapeutic potential of T-VEC in combination with MEK inhibitors in melanoma patients with NRAS mutation. Front Oncol. 2023 Mar 7;13:1111119. doi: 10.3389/fonc.2023.1111119. eCollection 2023

Steinfass T, Poelchen J, Sun Q, Mastrogiulio G, Novak D, Vierthaler M, Pardo S, Federico A, Hüser L, Hielscher T, Carretero R, Offringa R, Altevogt P, Umansky V, Utikal J. Secretogranin II influences the assembly and function of MHC class I in melanoma. Exp Hematol Oncol. 2023 Mar 11;12(1):29. doi: 10.1186/s40164-023-00387-1

Turco V, Pfleiderer K, Hunger J, Horvat NK, Karimian-Jazi K, Schregel K, Fischer M, Brugnara G, Jähne K, Sturm V, Streibel Y, Nguyen D, Altamura S, Agardy DA, Soni SS, Alsasa A, Bunse T, Schlesner M, Muckenthaler MU, Weissleder R, Wick W, Heiland S, Vollmuth P, Bendszus M, Rodell CB, Breckwoldt MO, Platten M. T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles. Nat Commun. 2023 Feb 11;14(1):771. doi: 10.1038/s41467-023-36321-6

Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J*, Wang X*, Cui G*. The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate. Nat Immunol. 2023 Nov;24(11):1921-1932. doi: 10.1038/s41590-023-01636-5. Epub 2023 Oct 9

Wolf L, Boutros M. The role of Evi/Wntless in exporting Wnt proteins. Development. 2023 Feb 15;150(3):dev201352. doi: 10.1242/dev.201352. Epub 2023 Feb 10. (Review)

2022

Arkhypov I, Özbay Kurt FG, Bitsch R, Novak D, Petrova V, Lasser S, Hielscher T, Groth C, Lepper A, Hu X, Li W, Utikal J, Altevogt P, Umansky V. HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling. J Immunother Cancer. 2022 Sep;10(9):e005551. doi: 10.1136/jitc-2022-005551

Bitsch R, Kurzay A, Özbay Kurt F, De La Torre C, Lasser S, Lepper A, Siebenmorgen A, Müller V, Altevogt P, Utikal J, Umansky V. STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice. J Immunother Cancer. 2022 Mar;10(3):e004384. doi: 10.1136/jitc-2021-004384

Bunse L, Bunse T, Kramer C, Chih YC, Platten M. (2022). Clinical and Translational Advances in Glioma Immunotherapy. Neurotherapeutics. 2022 Oct;19(6):1799-1817. doi: 10.1007/s13311-022-01313-9. Epub 2022 Oct 27. Review

Jauch AS*, Wohlfeil SA*, Weller C, Dietsch B, Häfele V, Stojanovic A, Kittel M, Nolte H, Cerwenka A, Neumaier M, Schledzewski K, Sticht C, Reiners-Koch PS, Goerdt S, Géraud C. Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis. Cancer Cell Int. 2022 Dec 10;22(1):398. doi: 10.1186/s12935-022-02800-x

Kehl N, Kilian M, Michel J, Wagner TR, Uhrig  S, Brobeil A, Sester LS, Blobner S, Steiger S, Hundemer M, Weinhold N, Rippe K , Fröhling S, Eichmüller SB, Bunse L, Müller-Tidow C, Goldschmidt H, Platten M, Raab MS, Friedrich MJ. IgE type multiple myeloma exhibits hypermutated phenotype and tumor reactive T cells. J Immunother Cancer. 2022 Oct;10(10):e005815. doi: 10.1136/jitc-2022-005815

Lu KHN, Michel J, Kilian M, Aslan K, Qi H, Kehl N, Jung S, Sanghvi K, Lindner K, Zhang XW, Green EW, Poschke I, Ratliff M, Bunse T, Sahm F, von Deimling A, Wick W, Platten M, Bunse L. T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells. Neurooncol Adv. 2022 Aug 31;4(1):vdac140. doi: 10.1093/noajnl/vdac140. eCollection 2022 Jan-Dec

Madi A, Weisshaar N, Buettner M, Poschet G, Ma S, Wu J, Mieg A, Hering M, Ming Y, Mohr K, Ten Bosch N, Cui G. CD8 agonism functionally activates memory T cells and enhances antitumor immunity. Int J Cancer. 2022 Sep 1;151(5):797-808. doi: 10.1002/ijc.34059. Epub 2022 May 21

Manta CP*, Leibing T*, Friedrich M, Nolte H, Adrian M, Schledzewski K, Krzistetzko J, Kirkamm C, Schmid CD, Xi Y, Stojanovic A, Tonack S, de la Torre C, Hammad S, Offermanns S, Krüger M, Cerwenka A, Platten M, Goerdt S*, Géraud C*. Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression. Circulation. 2022 Dec 6;146(23):1783-1799. doi: 10.1161/CIRCULATIONAHA.121.058615. Epub 2022 Nov 3

Özbay Kurt FG, Lepper A, Gerhards C, Roemer M, Lasser S, Arkhypov I, Bitsch R, Bugert P, Altevogt P, Gouttefangeas C, Neumaier M, Utikal J, Umansky V. Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2. Front Immunol. 2022 Oct 12:13:1012526. doi: 10.3389/fimmu.2022.1012526. eCollection 2022

Roy-Luzarraga M, Reynolds LE, de Luxán-Delgado B, Maiques O, Wisniewski L, Newport E, Rajeeve V, Drake RJG, Gómez-Escudero J, Richards FM, Weller C, Dormann C, Meng YM, Vermeulen PB, Saur D, Sanz-Moreno V, Wong PP, Géraud C, Cutillas PR, Hodivala-Dilke K. Suppression of Endothelial Cell FAK Expression Reduces Pancreatic Ductal Adenocarcinoma Metastasis after Gemcitabine Treatment. Cancer Res. 2022 May 16;82(10):1909-1925. doi: 10.1158/0008-5472.CAN-20-3807

Siegler JJ, Correia MP, Hofman T, Prager I, Birgin E, Rahbari NN, Watzl C, Stojanovic A, Cerwenka A. Human ILC3 Exert TRAIL-Mediated Cytotoxicity Towards Cancer Cells. Front Immunol. 2022 Mar 1:13:742571. doi: 10.3389/fimmu.2022.742571. eCollection 2022.

Stagno MJ, Schmidt A, Bochem J, Urla C, Handgretinger R, Cabanillas Stanchi KM, Saup R, Queudeville M, Fuchs J, Warmann SW, Schmid E. Epitope detection in monocytes (EDIM) for liquid biopsy including identification of GD2 in childhood neuroblastoma—a pilot study. Br J Cancer. 2022 Oct;127(7):1324-1331. doi: 10.1038/s41416-022-01855-x. Epub 2022 Jul 21

Tehranian C, Fankhauser L, Harter PN, Ratcliffe CDH, Zeiner PS, Messmer JM, Hoffmann DC, Frey K, Westphal D, Ronellenfitsch MW, Sahai E, Wick W, Karreman MA, Winkler F. The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis. Neuro Oncol. 2022 Feb 1;24(2):213-225. doi: 10.1093/neuonc/noab159

Vierthaler M, Sun Q, Wang Y, Steinfass T, Poelchen J, Hielscher T, Novak D, Umansky V, Utikal J. ADCK2 Knockdown Affects the Migration of Melanoma Cells via MYL6. Cancers (Basel). 2022 Feb 20;14(4):1071. doi: 10.3390/cancers14041071

Weisshaar N, Wu J, Ming Y, Madi A, Hotz-Wagenblatt A, Ma S, Mieg A, Hering M, Zettl F, Mohr K, Schlimbach T, Ten Bosch N, Hertel F, Müller L, Byren H, Wang M, Borgers H, Munz M, Schmitt L, van der Hoeven F, Kloz U, Carretero R, Schleußner N, Jackstadt RF, Hofmann I, Cui G. Rgs16 promotes antitumor CD8+ T cell exhaustion. Sci Immunol. 2022 May 27;7(71):eabh1873. doi: 10.1126/sciimmunol.abh1873. Epub 2022 May 27

Wohlfeil SA, Häfele V, Dietsch B, Weller C, Sticht C, Jauch AS, Winkler M, Schmid CD, Irkens AL, Olsavszky A, Schledzewski K, Reiners Koch PS, Goerdt S, Géraud C. Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti angiogenic treatment. J Transl Med. 2022 Feb 2;20(1):62. doi: 10.1186/s12967-022-03255-4

2021

Abdul Pari AA*, Singhal M*, Augustin HG. Emerging paradigms in metastasis research. J Exp Med. 2021 Jan 4;218(1):e20190218. doi: 10.1084/jem.20190218. (Review)

Barysch S, Stankovic-Valentin N, Miedema T, Karaca S, Doppel J, Thiziri Nait Achour, Vasudeva A, Wolf L, Sticht C, Urlaub H, Melchior F. Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling. EMBO Rep. 2021 Mar 3;22(3):e49651. doi: 10.15252/embr.201949651. Epub 2021 Jan 22

Berghoff AS, Liao Y, Karreman MA, Ilhan-Mutlu A, Gunkel K, Sprick MR, Eisen C, Kessler T, Osswald M, Wünsche S, Feinauer M, Gril B, Marmé F, Michel LL, Bago-Horvath Z, Sahm F, Becker N, Breckwoldt MO, Solecki G, Gömmel M, Huang L, Rübmann P, Thome CM, Ratliff M, Trumpp A, Steeg PS, Preusser M, Wick W, Winkler F. Identification and Characterization of Cancer Cells That Initiate Metastases to the Brain and Other Organs. Mol Cancer Res. 2021 Apr;19(4):688-701. doi: 10.1158/1541-7786.MCR-20-0863. Epub 2020 Dec 22

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, Breckwoldt MO, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 2021 Mar 4;137(9):1219-1232. doi: 10.1182/blood.2020005710

Friedrich M, Kehl N, Engelke N, Kraus J, Lindner K, Münch P, Mildenberger I, Groden C, Gass A, Etminan N, Fatar M, von Deimling A, Reuss D, Platten M, Bunse L. Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma. EMBO Mol Med. 2021 Aug 9; 13(8): e13953. Published online 2021 Jul 13. doi: 10.15252/emmm.202113953

Gebhardt C*, Simon SCS*, Weber R, Gries M, Mun DH, Reinhard R, Holland-Letz T, Umansky V, Utikal J. Potential therapeutic effect of low-dose paclitaxel in melanoma patients resistant to immune checkpoint blockade: A pilot study. Cell Immunol. 2021 Feb:360:104274. doi: 10.1016/j.cellimm.2020.104274. Epub 2020 Dec 28

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Baumann D, Gehrs S, Utikal J, Felcht M, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG. Timed Ang2-Targeted Therapy Identifies the Angiopoietin-Tie Pathway as Key Regulator of Fatal Lymphogenous Metastasis. Cancer Discov. 2021 Feb;11(2):424-445. doi: 10.1158/2159-8290.CD-20-0122. Epub 2020 Oct 26

Groth C, Arpinati L, Shaul ME, Winkler N, Diester K, Gengenbacher N, Weber R, Arkhypov I, Lasser S, Petrova V, Augustin HG, Altevogt P, Utikal J, Fridlender ZG, Umansky V. Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression. Cancers (Basel). 2021 Feb 10;13(4):726. doi: 10.3390/cancers13040726

Groth C, Weber R, Lasser S, Özbay FG, Kurzay A, Petrova V, Altevogt P, Utikal J, Umansky V. Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization. Int J Cancer. 2021 Nov 1;149(9):1628-1638. doi: 10.1002/ijc.33731. Epub 2021 Jul 17. (Review)

Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021; 12: 6963. Published online 2021 Nov 29. doi: 10.1038/s41467-021-27161-3

Koch PS, Sandorski K, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, de la Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch FA, Heineke J, Géraud C, Goerdt S, Olsavszky V. Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation. Front Physiol. 2021; 12: 722394. Published online 2021 Sep 29. doi: 10.3389/fphys.2021.722394

Kyjacova L, Saup R, Rothley M, Schmaus A, Wagner T, Boßerhoff A, Garvalov BK, Thiele W, Sleeman JP. Quantitative Detection of Disseminated Melanoma Cells by Trp-1 Transcript Analysis Reveals Stochastic Distribution of Pulmonary Metastases. J Clin Med. 2021 Nov; 10(22): 5459. Published online 2021 Nov 22. doi: 10.3390/jcm10225459

Kyjacova L, Saup R, Rönsch K, Wallbaum S, Dukowic-Schulze S, Foss A, Scherer SD, Rothley M, Neeb A, Grau N, Thiele W, Thaler S, Cremers N, Sticht C, Gretz N, Garvalov BK, Utikal J, Sleeman JP. IER2-induced senescence drives melanoma invasion through osteopontin. Oncogene. 2021; 40(47): 6494–6512. Published online 2021 Oct 5. doi: 10.1038/s41388-021-02027-6

Machiraju D, Wiecken M, Lang N, Hülsmeyer I, Roth J, Schank TE, Eurich R, Halama N, Enk A, Hassel JC. Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients. Oncoimmunology. 2021; 10(1): 1926762. Published online 2021 May 25. doi: 10.1080/2162402X.2021.1926762

Olsavszky V, Sticht C, Schmid CD, Winkler M, Wohlfeil SA, Olsavszky A, Schledzewski K, Géraud C, Goerdt S, Leibing T, Koch PS. Exploring the transcriptomic network of multi-ligand scavenger receptor Stabilin-1- and Stabilin-2-deficient liver sinusoidal endothelial cells. Gene. 2021 Feb 5;768:145284. doi: 10.1016/j.gene.2020.145284. Epub 2020 Oct 31

Pievani A, Savoldelli R, Poelchen J, Mattioli E, Anselmi G, Girardot A, Utikal J, Bourdely P, Serafini M, Guermonprez P. Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches. Front Immunol. 2021; 12: 631279. Published online 2021 Mar 15. doi: 10.3389/fimmu.2021.631279 (Review)

Robador JR, Feinauer MJ, Schneider SW, Mayer FT, Gorzelanny C, Sacharow A, Liu X, Berghoff A, Brehm MA, Hirsch D, Stadler J, Vidal-Y-Si S, Wladykowski E, Asong M, Nowak K, Seiz-Rosenhagen M, Umansky V, Mess C, Pantel K, Winkler F, Bauer AT. Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain. Neurooncol Adv. 2021 Nov 22;3(1):vdab175. doi: 10.1093/noajnl/vdab175. eCollection 2021 Jan-Dec

Schwab M, Lohr S, Schneider J, Kaiser M, Krunic D, Helbig D, Géraud C, Angel P. Podoplanin is required for tumor cell invasion in cutaneous squamous cell carcinoma. Exp Dermatol. 2021 Nov;30(11):1619-1630. doi: 10.1111/exd.14344. Epub 2021 Apr 9

Sedlmeier G, Al-Rawi V, Buchert J, Yserentant K, Rothley M, Steshina A, Gräßle S, Wu R-L, Hurrle T, Richer W, Decraene C, Thiele W, Utikal J, Abuillan W, Tanaka M, Herten D-P, Hill CS, Garvalov BK, Jung N, Bräse S, Sleeman JP. Id1 and Id3 Are Regulated Through Matrix-Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma. Adv. Therap. 2021 Feb;4(2): 2000065, doi: 10.1002/adtp.202000065. Epub 2020 Oct 12

Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn B, Kallenberg DM, Kulkarni SR, Camilli C, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide M, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG. Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci Transl Med. 2021 Sep;13(609):eabe6805. doi: 10.1126/scitranslmed.abe6805. Epub 2021 Sep 1

Sun Q, Novak D, Hüser L, Poelchen J, Wu H, Granados K, Federico A, Liu K, Steinfass T, Vierthaler M, Umansky V, Utikal J. FOXD1 promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor. Int J Cancer. 2021 Aug 1;149(3):657-674. doi: 10.1002/ijc.33591. Epub 2021 May 6

Weber R, Groth C, Lasser S, Arkhypov I, Petrova V, Altevogt P, Utikal J, Umansky V. IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy. Cell Immunol. 2021 Jan:359:104254. doi: 10.1016/j.cellimm.2020.104254. Epub 2020 Nov 29. (Review)

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2021 Feb;74(2):380-393. doi: 10.1016/j.jhep.2020.08.033. Epub 2020 Sep 9

Wolf L, Lambert A, Haenlin J, Boutros M. EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2. J Cell Sci. 2021 Aug 15;134(16):jcs257790. doi: 10.1242/jcs.257790. Epub 2021 Aug 18

Pievani A, Savoldelli R, Poelchen J, Mattioli E, Anselmi G, Girardot A, Utikal J, Bourdely P, Serafini M, Guermonprez P. Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches. Front Immunol. 2021; 12: 631279. Published online 2021 Mar 15. doi: 10.3389/fimmu.2021.631279 (Review)

2020

Abdul Pari AA*, Singhal M*, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Terhardt D, Geraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke KM, Augustin HG, Felcht M. Tumor Cell–Derived Angiopoietin-2 Promotes Metastasis in Melanoma. Cancer Res. 2020 Jun 15;80(12):2586-2598. doi: 10.1158/0008-5472.CAN-19-2660. Epub 2020 Apr 17

Arkhypov I, Lasser S, Petrova V, Weber R, Groth C, Utikal J, Altevogt P, Umansky V. Myeloid Cell Modulation by Tumor-Derived Extracellular Vesicles. Int J Mol Sci. 2020 Aug 31;21(17):6319. doi: 10.3390/ijms21176319. (Review)

Federico A, Steinfass T, Larribère L, Novak D, Morís F, Núñez LE, Umansky V, Utikal J. Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma. Mol Ther Oncolytics. 2020 Jun 4:18:83-99. doi: 10.1016/j.omto.2020.06.001. eCollection 2020 Sep 25

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, Breckwoldt MO, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 2020 Dec 3; blood.2020005710. doi: 10.1182/blood.2020005710. Online ahead of print.

Funck F, Pahl J, Kyjacova L, Freund L, Oehrl S, Gräbe G, Pezer S, Hassel JC, Sleeman J, Cerwenka A, Schäkel K. Human innate immune cell crosstalk induces melanoma cell senescence. Oncoimmunology. 2020; 9(1): 1808424. Published online 2020 Aug 30. doi: 10.1080/2162402X.2020.1808424

Granados K, Hüser L, Federico A, Sachindra S, Wolff G, Hielscher T, Novak D, Madrigal-Gamboa V, Sun Q, Vierthaler M, Larribère L, Umansky V, Utikal J. T-type calcium channel inhibition restores sensitivity to MAPK inhibitors in de-differentiated and adaptive melanoma cells. Br J Cancer. 2020 Mar;122(7):1023-1036. doi: 10.1038/s41416-020-0751-8. Epub 2020 Feb 17

Granados K, Poelchen J, Novak D, Utikal J. Cellular Reprogramming - A Model for Melanoma Cellular Plasticity. Int J Mol Sci. 2020 Nov 5;21(21):8274. doi: 10.3390/ijms21218274. (Review)

Hüser L, Kokkaleniou MM, Granados K, Dworacek J, Federico A, Vierthaler M, Novak D, Arkhypov I, Hielscher T, Umansky V, Altevogt P, Utikal J. HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma. Cancers (Basel). 2020 Dec 14;12(12):3761. doi: 10.3390/cancers12123761

Karimian-Jazi K, Münch P, Alexander A, Fischer M, Pfleiderer K, Piechutta M, Karreman MA, Solecki GM, Berghoff AS, Friedrich M, Deumelandt K, Kurz FT, Wick W, Heiland S, Bendszus M, Winkler F, Platten M, Breckwoldt MO. Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM). Theranostics. 2020 Jan 1;10(4):1873-1883. doi: 10.7150/thno.38659. eCollection 2020

Kim J, Novak D, Sachpekidis C, Utikal J, Larribère L. STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations. Cancers (Basel). 2020 Jan 2;12(1):119. doi: 10.3390/cancers12010119

Köhler F, Rodríguez-Paredes M. DNA Methylation in Epidermal Differentiation, Aging, and Cancer. J Invest Dermatol 2020 Jan;140(1):38-47. doi: 10.1016/j.jid.2019.05.011. Epub 2019 Aug 16. Review

Kovalchuk B, Berghoff AS, Karreman MA, Frey K, Piechutta M, Fischer M, Grosch J, Heiland S, Breckwoldt MO, Hilberg F, Wick W, Winkler F. Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells. Clin Exp Metastasis. 2020; 37(6): 637–648. Published online 2020 Sep 12. doi: 10.1007/s10585-020-10055-x

Martin-Garcia D, Silva-Vilches C, Will R, Enk AH, Lonsdorf AS. Tumor-derived CCL20 affects B16 melanoma growth in mice. J Dermatol Sci 2020 Jan;97(1):57-65. doi: 10.1016/j.jdermsci.2019.12.005. Epub 2019 Dec 13

Petrova V, Arkhypov I, Weber R, Groth C, Altevogt P, Utikal J, Umansky V. Modern Aspects of Immunotherapy with Checkpoint Inhibitors in Melanoma. Int J Mol Sci. 2020 Mar 30;21(7):2367. doi: 10.3390/ijms21072367. (Review)

Simon SCS, Hu X, Panten J, Grees M, Renders S, Thomas D, Weber R, Schulze TJ, Utikal J*, Umansky V*. Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors. OncoImmunology. 2020 Feb 15;9(1):1727116. doi: 10.1080/2162402X.2020.1727116. eCollection 2020. (*shared senior authorship)

Weber R, Riester Z, Hüser L, Sticht C, Siebenmorgen A, Groth C, Hu X, Altevogt P, Utikal JS, Umansky V. IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma. J Immunother Cancer. 2020 Aug;8(2):e000949. doi: 10.1136/jitc-2020-000949

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2020 Sep 9;S0168-8278(20)33608-4.  doi: 0.1016/j.jhep.2020.08.033. Online ahead of print

Wu J, Madi A, Mieg A, Hotz-Wagenblatt A, Weisshaar N, Ma S, Mohr K, Schlimbach T, Hering M, Borgers H, Cui G. T Cell Factor 1 Suppresses CD103+ lung tissue-resident memory T cell development. Cell Rep. 2020 Apr 7;31(1):107484. doi: 10.1016/j.celrep.2020.03.048

Wu J, Weisshaar N, Hotz-Wagenblatt A, Madi A, Ma S, Mieg A, Hering M, Mohr K, Schlimbach T, Borgers H, Cui G. Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion. Sci Adv. 2020 Jun 12;6(24):eaba3458. doi: 10.1126/sciadv.aba3458. eCollection 2020 Jun

2019

Fleming V, Hu X, Weller C, Weber R, Groth C, Riester Z, Hüser L, Sun Q, Nagibin V, Kirschning C, et al. Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling. Cancer Res 2019 Sep 15; 79 (18):4715–4728. doi:10.1158/0008-5472.CAN-19-0053

Groth C, Hu X, Weber R, Fleming V, Altevogt P, Utikal J, Umansky V. Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression. Br J Cancer. 2019 Jan;120(1):16-25. doi: 10.1038/s41416-018-0333-1. Epub 2018 Nov 9. (Review)

Hüser L, Altevogt P, Utikal J. Role of STAT3 dependent SOX2 and CD24 expression in melanoma cell adaptive resistance towards targeted therapies. Oncotarget. 2019 Mar 1;10(18):1662-1663. doi: 10.18632/oncotarget.26718.

Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J. Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability. Curr Biol. 2019 Jan 21;29(2):202-216.e7. doi: 10.1016/j.cub.2018.11.053. Epub 2019 Jan 10

Kloss L, Dollt C, Schledzewski K, Krewer A, Melchers S, Manta C, Sticht C, Torre C, Utikal J, Umansky V, Schmieder A. ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12. Cell Death Dis. 2019 Oct 7;10(10):760. doi: 10.1038/s41419-019-2010-6.

Orouji E*, Federico A*, Larribère L, Novak D, Lipka D, Assenov Y, Sachindra, Hüser L, Granados K, Gebhardt C, Plass C, Umansky V, Utikal J., 2019. The histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target.* Authors contributed equally. Int J Cancer. 2019 Dec 15; 145(12): 3462-3477. doi: 10.1002/ijc.32432

Simon SCS, Utikal J, Umansky V. Opposing roles of eosinophils in cancer. Cancer Immunol Immunother. 2019 May;68(5):823-833. doi: 10.1007/s00262-018-2255-4. Epub 2018 Oct 9. (Review)

Wagner NB, Weide B, Gries M, Reith M, Tarnanidis K, Schuermans V, Kemper C, Kehrel C, Funder A, Lichtenberger R, Sucker A, Herpel E, Holland-Letz T, Schadendorf D, Garbe C, Umansky V, Utikal J, Gebhardt C. Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies. J Immunother Cancer. 2019 Dec 5;7(1):343. doi: 10.1186/s40425-019-0828-1

Weber R, Umansky V. Fighting infant infections with myeloid-derived suppressor cells. J Clin Invest 2019 Oct 1; 129 (10):4080–4082. doi:10.1172/JCI131649

Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Malek Mohammadi M, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 2019 Feb 1;79(3):598-610. doi: 10.1158/0008-5472.CAN-18-1752.

2018

Bauer C, Abdul Pari AA, Umansky V, Utikal J, Boukamp P, Augustin HG, Goerdt S, Géraud C, Felcht M. 2018. T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin. Cancer Immunol Immunother. 2018 Jul;67(7):1147-1157

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, et al. CCR5 + Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res 2018 Jan 1; 78 (1):157–167. doi:10.1158/0008-5472.CAN-17-0348

Dix CL, Matthews HK, Uroz M, McLaren S, Wolf L, Heatley N, Win Z, Almada P, Henriques R, Boutros M, Trepat X, Baum B. 2018. The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division. Dev Cell. 2018 Apr 9;45(1):132-145.e3. doi: 10.1016/j.devcel.2018.03.009

Dollt, C*, Michel J*, Kloss, L*, Melchers, S, Schledzewski, K, Becker, K, Sauer, A, Krewer, A, Koll, F, Schmieder, A. 2018. The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration. Cell Death Dis. 2018 Sep 19;9(10):939. doi: 10.1038/s41419-018-1011-1

Fleming V, Hu X, Weber R, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V. 2018. Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression. Front Immunol. 2018 Mar 2;9:398. doi: 10.3389/fimmu.2018.00398. eCollection 2018. (Review)

Groth C, Hu X, Weber R, Fleming V, Altevogt P, Utikal J, Umansky V. Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression. Br J Cancer. 2018 Nov 9. doi: 10.1038/s41416-018-0333-1

Hüser L, Novak D, Umansky V, Altevogt P, Utikal J. Targeting SOX2 in anticancer therapy. Expert Opin Ther Targets. 2018 Dec 22(12):983-991

Hüser L, Sachindra, Granados K, Federico A, Larribère L, Novak D, Umansky V, Altevogt P, Utikal J, 2018. SOX2-mediated upregulation of CD24 promotes adaptive resistance towards targeted therapy in melanoma. Int J Cancer. 2018 Jun 15. doi: 10.1002/ijc.31609

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM. 2018. Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation. PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018. PMID: 29953488
200

Larribère L, Kuphal S, Sachpekidis C; Sachindra, Hüser L, Bosserhoff A, Utikal J. Targeted Therapy-Resistant Melanoma Cells Acquire Transcriptomic Similarities with Human Melanoblasts. Cancers (Basel). 2018 Nov 16;10(11)

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG., Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. 2018. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG., Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1

Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS. 2018. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Biochem Biophys Res Commun. 2018 Feb 26;497(1):32-38. doi: 10.1016/j.bbrc.2018.01.185. Epub 2018 Feb 1

Simon SCS, Utikal J, Umansky V. Opposing roles of eosinophils in cancer. Cancer Immunol Immunother. 2018 Oct 9. doi: 10.1007/s00262-018-2255-4. (Review)

Singhal S#, Liu X#, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG*, Hu J*: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, in press, Oct. 2018 (#,*equal contribution)

Weber R, Fleming V, Hu X, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V. 2018. Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors. Front Immunol. 2018 Jun 11;9:1310. doi: 10.3389/fimmu.2018.01310. eCollection

Weis CA, Kather JN, Melchers S, Al-Ahmdi H, Pollheimer MJ, Langner C, Gaiser T. Automatic evaluation of tumor budding in immunohistochemically stained colorectal carcinomas and correlation to clinical outcome. Diagn Pathol. 2018 Aug 28;13(1):64. doi:10.1186/s13000-018-0739-3

Wu, R*, Sedlmeier, G*, Kyjacova, L, Schmaus, A, Philipp, J, Thiele, W, Garvalov, BK, Sleeman, JP. Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3expression in melanoma cells. Sci Rep. 2018, 8:14913, doi:10.1038/s41598-018-33337-

2017

Dollt C, Becker K, Michel J, Melchers S,  Weis CA, Schledzewski K, Krewer A, Kloss L, Gebhardt C, Utikal J, Schmieder A, 2017. The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation. Oncotarget. 8:103682–103692. doi: 10.18632/oncotarget.21771

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen S, Pihlajaniemi T, Arnold B, Rodewald H, Augustin HG, Schledzewski K, Goerdt S, 2017. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 127:1099-1114. doi: 10.1172/JCI90086.

Horn S, Hughes MA, Schilling R, Sticht C, Tenev T, Ploesser M, Sprick MR, Meier P, MacFarlane M, Leverkus M, 2017. Caspase-10 Negatively Regulates Caspase-8- Mediated Cell Death, Switching the Response to CD95L in Favor of NF- k B Activation and Cell Survival. Cell Reports 19:785–797. doi:10.1016/j.celrep.2017.04.010

Kather JN, Zöllner FG, Schad LR, Melchers SM, Sinn HP, Marx A, Gaiser T, Weis CA. Identification of a characteristic vascular belt zone in human colorectal cancer [published correction appears in PLoS One. 2017 May 8;12 (5):e0177586]. PLoS One. 2017 Mar 2;12(3):e0171378. doi: 10.1371/journal.pone.0171378. eCollection 2017

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S, Géraud C, 2017. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129:415–420. doi:10.1182/blood-2016-07-729822

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantz H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS, 2017.  GATA4 and LMO3 balance angiocrine signalling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 5;627:491-499. doi: 10.1016/j.gene.2017.06.051

Sachindra, Larribère L, Novak D, Wu H, Hüser L, Granados K, Orouji E, Utikal J, 2017. New role of ID3 in melanoma adaptive drug-resistance. Oncotarget. 8:110166–110175. doi: 10.18632/oncotarget.22698
12.    Sedlmeier, G, Sleeman JP, 2017. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem. Soc. Trans. 45:173–181. doi:10.1042/BST20160263

Sedlmeier G, Sleeman JP. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem Soc Trans. 2017 Feb 8;45(1)173–181. doi: 10.1042/BST20160263. (Review)

2016

Goertz L*, Schneider SW*, Desch A, Mayer FT, Koett J, Nowak K, Karampinis I, Bohlmann MK, Umansky V, Bauer AT, 2016. Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget 7:68527–45. doi:10.18632/oncotarget.11832

Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JWR, Leverkus M, Cain K, MacFarlane M, 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol. Cell 61:834–849. doi:10.1016/j.molcel.2016.02.023

Kather JN, Weis CA, Bianconi F, Melchers SM, Schad LR, Gaiser T, Marx A, Zöllner FG. Multi-class texture analysis in colorectal cancer histology. Sci Rep. 2016 Jun 16:6:27988. doi:10.1038/srep27988

Krachulec JM, Sedlmeier G, Thiele W, Sleeman JP, 2016. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem. Cell Biol. 94:289–96. doi:10.1139/bcb-2015-0150

Weina K*, Wu H*, Knappe N, Orouji E, Novak D, Bernhardt M, Hüser L, Larribère L, Umansky V, Gebhardt C, Utikal J, 2016. TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells. Pigment Cell Melanoma Res. 29:453–458. doi:10.1111/pcmr.12483

2015

Geserick P, Wang J, Schilling R, Horn S, Harris PA, Bertin J, Gough PJ, Feoktistova M, Leverkus M. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 2015 Sep 10;6:e1884. doi:10.1038/cddis.2015.240

2021

Shen Y*, Wang X*, Liu Y, Singhal M, Gürkaslar C, Freire Valls A, Lei Y, Hu W, Schermann G, Adler H, Yu FX, Fischer T, Zhu Y, Augustin HG, Schmidt T, Ruiz de Almodovar C. STAT3-YAP/TAZ signaling in endothelial cells promotes tumor angiogenesis. Sci Signal. 2021 Dec7;14(712):eabj8393. doi: 10.1126/scisignal.abj8393. Epub 2021 Dec 7

2020

Shevchenko I, Mathes A, Groth C, Karakhanova S, Müller V, Utikal J, Werner J, Bazhin AV, Umansky V. Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses. Oncoimmunology. 2020 Apr 9;9(1):1744946. doi: 10.1080/2162402X.2020.1744946

2019

Jäger K*, Larribère L*, Wu H, Weiss C, Gebhardt C, Utikal J. Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis. Cancers (Basel). 2019 Jan 11;11(1):76. doi: 10.3390/cancers11010076. OA.

Sharbi-Yunger A, Grees M, Gal C, Bassan D, Eichmüller SB, Tzehoval E, Utikal J, Umansky V, Eisenbach L. A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival. Int J Cancer. 2019 Feb 15;144(4):909-921. doi: 10.1002/ijc.31795. Epub 2018 Dec 5.

Umansky V, Adema GJ, Baran J, Brandau S, Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG. Interactions among myeloid regulatory cells in cancer. Cancer Immunol Immunother. 2019 Apr;68(4):645-660. doi: 10.1007/s00262-018-2200-6. Epub 2018 Jul 12. (Review)

2018

Jäger K*, Larribère L*, Wu H, Weiss C, Gebhardt C, Utikal J. Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis. Cancers (Basel). 2019, 11 (1), 76; doi: 10.3390/cancers11010076

Fleming V, Umansky V, 2018. Two MDSC faces in obesity: Correcting metabolic dysfunctions but promoting tumor development. J Leukoc Biol. 103:373-375. doi: 10.1002/JLB.3CE1017-416R.

Huber V, Vallacchi V, Fleming V, Hu X, Cova A, Dugo M, Shahaj E, Sulsenti R, Vergani E, Filipazzi P, De Laurentiis A, Lalli L, Di Guardo L, Patuzzo R, Vergani B, Casiraghi E, Gualeni A, Bollati V, Arienti F, Mariani L, Villa A, Altevogt P, Umansky V, Rodolfo M, Rivoltini L. MDSC-miRs convey immune suppressive properties to monocytes in melanoma. J Clin Invest, 2018 Nov 5. pii: 98060. doi: 10.1172/JCI98060.
202

Sharbi-Yunger A, Grees M, Gal C, Bassan D, Eichmüller SB, Tzehoval E, Utikal J, Umansky V, Eisenbach L. 2018. A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival. Int J Cancer. 2018 Aug 14. doi: 10.1002/ijc.31795.

Umansky V, Adema GJ, Baran J., Brandau S., Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG. 2018. Interactions among myeloid regulatory cells in cancer. Cancer Immunol Immunother. Epub 2018 Jul 12. doi: 10.1007/s00262-018-2200-6.

Wu H, Larribère L, Sun Q, Novak D, Sachindra S, Granados K, Umansky V, Utikal J. 2018. Loss of neural crest-associated gene FOXD1 impairs melanoma invasion and migration via RAC1B downregulation. Int J Cancer. 2018 Aug 15. doi: 10.1002/ijc.31799.

Wu H, Huang J. Drug-Induced Nephrotoxicity: Pathogenic Mechanisms, Biomarkers and Prevention Strategies. Curr Drug Metab. 2018;19(7):559-567. doi: 10.2174/1389200218666171108154419. (Review)

Wu H, Huang J. Optimization of Protein and Peptide Drugs Based on the Mechanisms of Kidney Clearance. Protein Pept Lett. 2018;25(6):514-521. doi: 10.2174/0929866525666180530122835. (Review)

Yamauchi Y, Safi S, Blattner C, Rathinasamy A, Umansky L, Juenger S, Warth A, Eichhorn M, Muley T, Herth FJF, Dienemann H, Platten M, Beckhove P, Utikal J, Hoffmann H, Umansky V, 2018. Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-small-cell Lung Cancer. Am J Respir Crit Care Med. 2018 in press.

Grees M, Sharbi-Yunger A, Evangelou C, Baumann D, Cafri G, Tzehoval E, Eichmüller SB, Offringa R, Utikal J, Eisenbach L, Umansky V. 2018. Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models. Oncoimmunology. 2018 Mar 26;7(7):e1445457. doi: 10.1080/2162402X.2018.1445457. eCollection 2018

2017

Desch A, Gebhardt C, Utikal J, Schneider SW, 2017. D-dimers in malignant melanoma: Association with prognosis and dynamic variation in disease progress. Int J Cancer 140:914-921 doi:10.1002/ijc.30498

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N, 2017. CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development. Cell Rep. 21:2212-2222. doi: 10.1016/j.celrep.2017.10.104.

Umansky V, Blattner C, Gebhardt C, Utikal J, 2017. CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma. Cancer Immunol Immunother. 2017 Aug;66(8):1015-1023. doi: 10.1007/s00262-017-1988-9.

Umansky V, Blattner C, Fleming V, Hu X, Gebhardt C, Altevogt P, Utikal J, 2017. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin Immunopathol. 39:295-305.

2016

Fehrenbach S, Novak D, Bernhardt M, Larribere L, Boukamp P, Umansky V, Utikal J, 2016. Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci Rep 6:1–12. doi:10.1038/srep28891

Jacquelot N, Enot DP, Flament C, Vimond N, Blattner C, Pitt JM, Yamazaki T, Roberti MP, Daillère R, Vétizou M, Poirier-Colame V, Semeraro M, Caignard A, Slingluff CL Jr, Sallusto F, Rusakiewicz S, Weide B, Marabelle A, Kohrt H, Dalle S, Cavalcanti A, Kroemer G, Di Giacomo AM, Maio M, Wong P, Yuan J, Wolchok J, Umansky V, Eggermont A, Zitvogel L, 2016. Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma. J Clin Invest. 126:921-37. doi: 10.1172/JCI80071.

Sharbi-Yunger A, Grees M, Tzehoval E, Utikal J, Umansky V, Eisenbach L. mRNA-based dendritic cell immunization improves survival in ret transgenic mouse melanoma model. Oncoimmunology. 2016 Apr 22;5(6):e1160183. doi: 10.1080/2162402X.2016.1160183. eCollection 2016 Jun

Tähtinen S, Blattner C, Vähä-Koskela M, Saha D, Siurala M, Parviainen S, Utikal J, Kanerva A, Umansky V, Hemminki A, 2016. T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma. J Immunother. 39:343-354.

Umansky, V, Blattner, C, Gebhardt, C, Utikal, J, 2016. The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression. Vaccines 4. doi:10.3390/vaccines4040036

2015

Bauer AT*, Suckau J*, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-valdes N, Umansky V, Schneider SW, 2015. von Willebrand factor fi bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood 125:3153–3164. doi:10.1182/blood-2014-08-595686.A.T.B.

Messmer JM, Thommek C, Piechutta M, Venkataramani V, Wehner R, Westphal D, Schubert M, Mayer CD, Effern M, Berghoff AS, Hinze D, Helfrich I, Schadendorf D, Wick W, Hölzel M, Karreman MA*, Winkler F*. T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels. Immunity. 2024 Sep 28:S1074-7613(24)00447-3. doi: 10.1016/j.immuni.2024.09.003. Online ahead of print

Ma S*, Sandhoff R*, Luo X*, Shang F*, Shi Q, Li Z, Wu J, Ming Y, Schwarz F, Madi A, Weisshaar N, Mieg A, Hering M, Yan X, Mohr K, ten Bosch N, Li Z, Poschet G, Rodewald HR, Papavasiliou N, Wang X, Gao P, Cui G. 2024. Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos. Sci Immunol. 2024 Apr 19;9(94):eadg8817. doi: 10.1126/sciimmunol.adg8817. Epub 2024 Apr 19

Tan CL, Lindner K, Boschert T, Meng Z, Rodriguez Ehrenfried A, De Roia A, Haltenhof G, Faenza A, Imperatore F, Bunse L, Lindner JM, Harbottle RP, Ratliff M, Offringa R, Poschke I, Platten M*, Green EW*. Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy. Nat Biotechnol. 2024 Mar 7. doi: 10.1038/s41587-024-02161-y. Online ahead of print. (*equal contribution)

Hausmann D, Hoffmann DC, Venkataramani V, Jung E, Horschitz S, Tetzlaff SK, Jabali A, Hai L, Kessler T, Azoŕin DD, Weil S, Kourtesakis A, Sievers P, Habel A, Breckwoldt MO, Karreman MA, Ratliff M, Messmer JM, Yang Y, Reyhan E, Wendler S, Löb C, Mayer C, Figarella K, Osswald M, Solecki G, Sahm F, Garaschuk O, Kuner T, Koch P, Schlesner M, Wick W, Winkler F. Autonomous rhythmic activity in glioma networks drives brain tumour growth. Nature. 2023 Jan;613(7942):179-186. doi: 10.1038/s41586-022-05520-4. Epub 2022 Dec 14

Hübers C, Abdul Pari AA, Grieshober D, Petkov M, Schmidt A, Messmer T, Heyer CM, Schölch S, Kapel SS, Gengenbacher N, Singhal M, Schieb B, Fricke C, Will R, Remans K, Utikal JS, Reissfelder C, Schlesner M, Hodivala-Dilke KM, Kersten S, Goerdt S, Augustin HG*, Felcht M*. Primary tumor-derived systemic nANGPTL4 inhibits metastasis. J Exp Med. 2023 Jan 2; 220(1):e20202595. doi: 10.1084/jem.20202595. Epub 2022 Oct 21. (*equally contributing senior authors)

Schmid CD*; Olsavszky V*, Reinhart M*, Weyer V, Trogisch FA, Sticht C, Winkler M, Kürschner SW, Hoffmann J, Ola R, Staniczek T, Heineke J, Straub BK, Mittler J, Schledzewski K, Ten Dijke P, Richter K, Dooley S, Géraud C, Goerdt S*, Koch PS*. ALK1 Controls Hepatic Vessel Formation, Angiodiversity, and Angiocrine Functions in Hereditary Hemorrhagic Telangiectasia of the Liver. Hepatology. 2023 Apr 1;77(4):1211-1227. doi: 10.1002/hep.32641. Epub 2022 Jul 17. (*equal contribution)

Weisshaar N, Ma S, Ming Y, Madi A, Mieg A, Hering M, Zettl F, Mohr K, ten Bosch N, Stichling D, Buettner M, Poschet G, Klinke G, Schulz M, Kunze-Rohrbach N, Kerber C, Klein IM, Wu J, Wang X, Cui G. The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate. Nat Immunol. 2023 Nov;24(11): 1921-1932. doi:10.1038/s41590-023-01636-5. Epub 2023 Oct 9

Manta CP*, Leibing T*, Friedrich M, Nolte H, Adrian M, Schledzewski K, Krzistetzko J, Kirkamm C, Schmid CD, Xi Y, Stojanovic A, Tonack S, de la Torre C, Hammad S, Offermanns S, Krüger M, Cerwenka A, Platten M, Goerdt S*, Géraud C*. 2022. Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression. Circulation. 2022 Dec 6;146(23):1783-1799. doi: 10.1161/CIRCULATIONAHA.121.058615. Epub 2022 Nov 3. (*equal contribution)

Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, Breckwoldt MO, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F. 2021. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 2021 Mar 4;137(9):1219-1232. doi: 10.1182/blood.2020005710

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG. 2021. Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov. 2021 Feb;11(2):424-445. doi: 10.1158/2159-8290.CD-20-0122. Epub 2020 Oct 26

Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S*, Koch PS*. 2021. Bone Marrow Sinusoidal Endothelium Controls Terminal Erythroid Differentiation and Reticulocyte Maturation. Nat Commun. 2021 Nov 29;12(1):6963. doi: 10.1038/s41467-021-27161-3. (*equal contribution)

Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuss SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG. 2021. Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Sci Transl Med. 2021 Sep;13(609):eabe6805. doi: 10.1126/scitranslmed.abe6805. Epub 2021 Sep 1. (*equally contributing first authors)

Winkler M*, Staniczek T*, Kürschner SW*, Schmid CD*, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C*, Koch PS*, Goerdt S*. 2021. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2021 Feb; 74(2):380-393. doi: 10.1016/j.jhep.2020.08.033. Epub 2020 Sep 9. (*equal contribution)

Ni J*, Wang X*, Stojanovic A*, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. 2020. Single-cell RNA sequencing of tumor-infiltrating NK cells reveals that inhibition of transcription factor HIF-1α unleashes NK cell activity. Immunity. 2020 Jun 16;52(6):1075-1087.e8. doi: 10.1016/j.immuni.2020.05.001. Epub 2020 May 22. (*equal contribution)

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V. CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res. 2018 Jan 1;78(1):157-167. doi: 10.1158/0008-5472.CAN-17-0348. Epub 2017 Oct 31

La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HC, Savant S, Augustin HG. Endothelial Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest. 2018 Feb 1;128(2):834-845. doi: 10.1172/JCI94674. Epub 2018 Jan 22

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M. Toward an integrated map of genetic interactions in cancer cells. Mol Syst Biol. 2018 Feb 21;14(2):e7656. doi: 10.15252/msb.20177656

Augustin HG, Koh GY. 2017. Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology. Science. 2017 Aug 25;357(6353).eaal2379. doi: 10.1126/science.aal2379. Epub 2017 Aug 3. (Review)

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood. 2017 Jan 26;129(4):415-419. doi: 10.1182/blood-2016-07-729822. Epub 2016 Nov 30

Dr. Ashik Pari
The role of tumor cell-expressed Angiopoietin 2 in malignant melanoma

Dr. Verena Häfele
Liver-specific endothelial mechanisms of melanoma metastasis

Dr. Sina Kürschner-Zacharias
Endothelial regulation of liver fibrosis

Dr. Juliane Poelchen
Generation of melanoma antigen-specific CD8+ T cells from human induced pluripotent stem cells for adoptive cell therapy

Dr. Julia Meßmer
Dynamic intravital imaging reveals a recruitment mechanism to melanoma brain tumors

Dr. Tomáš Hofman
Defining innate immune checkpoints controlling NK cell recognition of melanoma cells

Dr. Rafael Saup
A mechanistic evaluation of melanoma metastasis and therapy resistance

Dr. Céline Weller
Pre-metastatic and immunological conditioning of the hepatic niche during melanoma progression

Dr. Denise Grieshober
The role of the N-fragment of Angiopoietin-like 4 in malignant melanoma metastasis formation

Dr. Saskia Tauch
Communication between tumour cells and fibroblasts in the tumour microenvironment during melanoma progression

Dr. Johannes Hoffmann
Der Einfluss einer pathologisch veränderten vaskulären Nische auf die Lebermetasta-sierung des malignen Melanoms

Dr. Iris Müller
Inhibiting glucocorticoid receptor signalling in tumour-associated macrophages for anti-tumour immune response

Dr. Dennis Agardy
Immune cell dynamics in irradiated gliomas

Dr. Marvin Hering
Sptlc2-derived sphinganine is indispensable for inflammatory TLR4 signaling in macrophages

Dr. Samantha Lasser
MDSC activation mediated by extracellular vesicles-associated microRNA in melanoma

Dr. Lucie Wolf
Ubiquitin-dependent regulation of the WNT cargo protein EVI/WLS

Dr. Rebekka Weber
Regulation of CCR5 expression and immunosuppressive phenotype of MDSC in melanoma

Dr. Felix Funck
Innate immune cell crosstalk induces melanoma cell senescence

Dr. José Robador Arteta
Crosstalk between melanoma cells and the blood-brain barrier: impact on coagulation and brain metastasis to identify new anti-metastatic targets

Dr. Melanie Schwab
Function of the mucin-like glycoprotein Podoplanin in the progression of cutaneous squamous cell carcinoma

Dr. Florian Köhler
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome

Dr. Katharina Kober
Elucidating the role of Wnt secretion in cutaneous squamous cell carcinoma (cSCC)

Dr. Loreen Kloss
Molecular and Functional Characterization of P2Y12 Expression in Tumor-associated Macrophages

Dr. Federico Aniello
Molecular and functional characterization of the role of the histone methyltransferase SETDB1 in malignant melanoma

Dr. Diego Martin Garcia
Characterization and modulation of CC-chemokine receptor 6 (CCR6)-mediated immune-surveillance in malignant melanoma

Dr. Georg Sedlmeier
The role of ld proteins in determining the tumor initiating and metastatic properties of melanoma cells

Dr. Johanna Zierow
Investigation of liver sinusoidal endothelial cells – Characterisation and application of new transgenic mouse models

Dr. Laura Hüser
The role of SOX2 in resistance towards targeted therapy

Dr. Ramon Schilling
Identification and characterisation of novel components involved in Ripoptosome mediated signal transduction

Dr. Sebastian Horn
Die Rolle der Caspase-10 in der Zelltodresistenz des malignen Melanoms

Dr. Andreas Krewer
Immunopheno-typing of the myeloid-specific glucocorticoid receptor knock-out mouse model GRLysMCre and its implications for melanoma growth

Dr. Tatjana Meßmer
Funktionelle Analyse von Angiopoietin-like 4 Protein während der Tumorangiogenese

Dr. Manuel Feinauer
Impact of platelets and coagulation factors on the brain metastatic cascade

Dr. Sonja Simon
Eosinophils as biomarker in melanoma immunotherapy and solid tumors

Dr. Susanne Melchers
Identification of Corticotropin Releasing Factor and Corticotropin Releasing Factor Receptor 1 and 2 in macrophages in melanocytic naevi and melanoma and correlation with clinical data

Dr. Julian Kött
Die Rolle des von Willebrand Faktors im Plasma und Tumorgewebe im Hinblick auf tumorassoziierte Thromboembolien, Progression und Mortalität maligner Tumorentitäten

Dr. James Kim
STAT3 – the switch of melanoma-associated NRAS mutations

Dr. Bogdana Kovalchuk

Faktoren der frühen Gehirnkolonialisierung von metastatischen Tumorzellen: Einfluss des Primärtumors und antiangiogene Präventionskonzepte

Dr. Mirko Gries
Dynamik humoraler und zellulärer Immunparameter als prädiktive Biomarker in der Immuntherapie des metastasierten Melanoms

Dr. Anna Jauch
Die Bedeutung von Lyve-1 für die Leber und seine Rolle während der hepatischen Metastasierung

Dr. Ihor Arkhypov
HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling

Dr. Theresa Staniczek
Endothelial regulation of liver homeostasis and regeneration

Dr. Christopher Groth
Myeloid-derived suppressor cell (MDSC) recruitment and function in primary and metastatic melanoma lesions

Dr. Marlene Vierthaler
The influence of ADCK2 on melanoma cells and during the development to melanocytic progenitors (NCCs)

Dr. Marlene Steinfass
The influence of secretogranin 2 on the assembly and presentation of the MHC class I complex in melanoma

Dr. Bianca Dietsch
Tumorintrinsische Promotoren der hepatischen Metastasierung

Dr. Qian Sun
The role of FOXD1 in melanoma dedifferentiation and resistance towards targeted therapy

Dr. Feyza Gül Ozbay Kurt
Targeting MDSC-mediated immune-suppression in melanoma

Dr. Thomas Leibing
Angiokrine Liganden des Wnt Signalwegs kontrollieren die Lebergröße und die metabolische Zonierung der Hepatozyten in Mäusen

Dr. Christian Schmid
Zelltypspezifische Charakterisierung des humanen G-Protein-gekoppelten Rezeptors 182 (GPR182)

Dr. Karol Granados Blanco
Partial reprogramming – a model for melanoma targeted therapy resistance

Dr. Xiaoying Hu
Role of tumor-derived extracellular vesicles in immunosuppression in malignant melanoma patients

Dr. Viktor Fleming
Role of tumor-derived exosomes in the induction of immunosuppression in melanoma

Dr. Carolin Blattner
The Role of CCR5 in the Recruitment of MDSC to the Tumor Microenvironment

Dr. Claudia Dollt
Analysis of the Relevance of LYVE-1+ Tumor-associated Macrophages of Melanoma.

Dr. Sabrina Fehrenbach
Loss of tumorigenicity by transdifferentiation: from squamous cell carcinoma to melanocyte-like cells.

Dr. Mareike Grees
Improved dendritic cell vaccination for combined melanoma immune therapy

Dr. Lisa Schardt
The impact of Cyclosporine A on human epidermal keratinocytes

Dr. Huizi Wu
The role of neural crest specific genes in melanoma pathogenesis

To date no MD theses have been completed.