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Publications & Theses


Publications by PhD and MD students of the RTG 2099 since 2015


Wohlfeil SA, Häfele V, Dietsch B, Weller C, Sticht C, Jauch AS, Winkler M, Schmid CD, Irkens AL, Olsavszky A, Schledzewski K, Reiners‑Koch PS, Goerdt S, Géraud C. Angiogenic and molecular diversity determine hepatic melanoma metastasis and response to anti‑angiogenic treatment. J Transl Med. 2022; 20:62. doi: 10.1186/s12967-022-03255-4. Online ahead of print.


Heil J*, Olsavszky V*, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS. Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation. Nat Commun. 2021; 12: 6963. Published online 2021 Nov 29. doi: 10.1038/s41467-021-27161-3

Kyjacova L, Saup R, Rothley M, Schmaus A, Wagner T, Boßerhoff A, Garvalov BK, Thiele W, Sleeman JP. Quantitative Detection of Disseminated Melanoma Cells by Trp-1 Transcript Analysis Reveals Stochastic Distribution of Pulmonary Metastases. J Clin Med. 2021 Nov; 10(22): 5459. Published online 2021 Nov 22. doi: 10.3390/jcm10225459

Kyjacova L, Saup R, Rönsch K, Wallbaum S, Dukowic-Schulze S, Foss A, Scherer SD, Rothley M, Neeb A, Grau N, Thiele W, Thaler S, Cremers N, Sticht C, Gretz N, Garvalov BK, Utikal J, Sleeman JP. IER2-induced senescence drives melanoma invasion through osteopontin. Oncogene. 2021; 40(47): 6494–6512. Published online 2021 Oct 5. doi: 10.1038/s41388-021-02027-6

Koch PS, Sandorski K, Heil J, Schmid CD, Kürschner SW, Hoffmann J, Winkler M, Staniczek T, de la Torre C, Sticht C, Schledzewski K, Taketo MM, Trogisch FA, Heineke J, Géraud C, Goerdt S, Olsavszky V. Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation. Front Physiol. 2021; 12: 722394. Published online 2021 Sep 29. doi: 10.3389/fphys.2021.722394

Friedrich M, Kehl N, Engelke N, Kraus J, Lindner K, Münch P, Mildenberger I, Groden C, Gass A, Etminan N, Fatar M, von Deimling A, Reuss D, Platten M, Bunse L. Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma. EMBO Mol Med. 2021 Aug 9; 13(8): e13953. Published online 2021 Jul 13. doi: 10.15252/emmm.202113953

Machiraju D, Wiecken M, Lang N, Hülsmeyer I, Roth J, Schank TE, Eurich R, Halama N, Enk A, Hassel JC. Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients. Oncoimmunology. 2021; 10(1): 1926762. Published online 2021 May 25. doi: 10.1080/2162402X.2021.1926762

Pievani A, Savoldelli R, Poelchen J, Mattioli E, Anselmi G, Girardot A, Utikal J, Bourdely P, Serafini M, Guermonprez P. Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches. Front Immunol. 2021; 12: 631279. Published online 2021 Mar 15. doi: 10.3389/fimmu.2021.631279 (Review)


Feinauer MJ, Schneider SW, Berghoff AS, Robador JR, Tehranian C, Karreman MA, Venkataramani V, Solecki G, Grosch JK, Gunkel K, Kovalchuk B, Mayer FT, Fischer M, Breckwoldt MO, Brune M, Schwab Y, Wick W, Bauer AT, Winkler F. Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model. Blood. 2020 Dec 3; blood.2020005710. doi: 10.1182/blood.2020005710. Online ahead of print.

Kovalchuk B, Berghoff AS, Karreman MA, Frey K, Piechutta M, Fischer M, Grosch J, Heiland S, Breckwoldt MO, Hilberg F, Wick W, Winkler F. Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells. Clin Exp Metastasis. 2020; 37(6): 637–648. Published online 2020 Sep 12. doi: 10.1007/s10585-020-10055-x

Winkler M, Staniczek T, Kürschner SW, Schmid CD, Schönhaber H, Cordero J, Kessler L, Mathes A, Sticht C, Neßling M, Uvarovskii A, Anders S, Zhang XJ, von Figura G, Hartmann D, Mogler C, Dobreva G, Schledzewski K, Géraud C, Koch PS, Goerdt S. Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling. J Hepatol. 2020 Sep 9;S0168-8278(20)33608-4.  doi: 0.1016/j.jhep.2020.08.033. Online ahead of print

Funck F, Pahl J, Kyjacova L, Freund L, Oehrl S, Gräbe G, Pezer S, Hassel JC, Sleeman J, Cerwenka A, Schäkel K. Human innate immune cell crosstalk induces melanoma cell senescence. Oncoimmunology. 2020; 9(1): 1808424. Published online 2020 Aug 30. doi: 10.1080/2162402X.2020.1808424

Köhler F, Rodríguez-Paredes M. DNA Methylation in Epidermal Differentiation, Aging, and Cancer. J Invest Dermatol 2020 Jan;140(1):38-47. doi: 10.1016/j.jid.2019.05.011. Epub 2019 Aug 16. Review

Martin-Garcia D, Silva-Vilches C, Will R, Enk AH, Lonsdorf AS. Tumor-derived CCL20 affects B16 melanoma growth in mice. J Dermatol Sci 2020 Jan;97(1):57-65. doi: 10.1016/j.jdermsci.2019.12.005. Epub 2019 Dec 13


Orouji E*, Federico A*, Larribère L, Novak D, Lipka D, Assenov Y, Sachindra, Hüser L, Granados K, Gebhardt C, Plass C, Umansky V, Utikal J., 2019. The histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target.* Authors contributed equally. Int J Cancer. 2019 Dec 15; 145(12): 3462-3477. doi: 10.1002/ijc.32432

Kloss L, Dollt C, Schledzewski K, Krewer A, Melchers S, Manta C, Sticht C, Torre C, Utikal J, Umansky V, Schmieder A. ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12. Cell Death Dis. 2019 Oct 7;10(10):760. doi: 10.1038/s41419-019-2010-6.

Weber R, Umansky V. Fighting infant infections with myeloid-derived suppressor cells. J Clin Invest 2019 Oct 1; 129 (10):4080–4082. doi:10.1172/JCI131649

Fleming V, Hu X, Weller C, Weber R, Groth C, Riester Z, Hüser L, Sun Q, Nagibin V, Kirschning C, et al. Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling. Cancer Res 2019 Sep 15; 79 (18):4715–4728. doi:10.1158/0008-5472.CAN-19-0053

Hüser L, Altevogt P, Utikal J. Role of STAT3 dependent SOX2 and CD24 expression in melanoma cell adaptive resistance towards targeted therapies. Oncotarget. 2019 Mar 1;10(18):1662-1663. doi: 10.18632/oncotarget.26718.

Wohlfeil SA*, Häfele V*, Dietsch B, Schledzewski K, Winkler M, Zierow J, Leibing T, Malek Mohammadi M, Heineke J, Sticht C, Olsavszky V, Koch PS, Géraud C*, Goerdt S*: Hepatic endothelial Notch activation protects against liver metastasis by regulating endothelial-tumor cell adhesion independent of angiocrine signaling. Cancer Res. 2019 Feb 1;79(3):598-610. doi: 10.1158/0008-5472.CAN-18-1752.


Hüser L, Novak D, Umansky V, Altevogt P, Utikal J. Targeting SOX2 in anticancer therapy. Expert Opin Ther Targets. 2018 Dec 22(12):983-991

Larribère L, Kuphal S, Sachpekidis C; Sachindra, Hüser L, Bosserhoff A, Utikal J. Targeted Therapy-Resistant Melanoma Cells Acquire Transcriptomic Similarities with Human Melanoblasts. Cancers (Basel). 2018 Nov 16;10(11)

Groth C, Hu X, Weber R, Fleming V, Altevogt P, Utikal J, Umansky V. Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression. Br J Cancer. 2018 Nov 9. doi: 10.1038/s41416-018-0333-1

Simon SCS, Utikal J, Umansky V. Opposing roles of eosinophils in cancer. Cancer Immunol Immunother. 2018 Oct 9. doi: 10.1007/s00262-018-2255-4. (Review)

Wu, R*, Sedlmeier, G*, Kyjacova, L, Schmaus, A, Philipp, J, Thiele, W, Garvalov, BK, Sleeman, JP. Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3expression in melanoma cells. Sci Rep. 2018, 8:14913, doi:10.1038/s41598-018-33337-7

Dollt, C*, Michel J*, Kloss, L*, Melchers, S, Schledzewski, K, Becker, K, Sauer, A, Krewer, A, Koll, F, Schmieder, A. 2018. The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration. Cell Death Dis. 2018 Sep 19;9(10):939. doi: 10.1038/s41419-018-1011-1

Singhal S#, Liu X#, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG*, Hu J*: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, in press, Oct. 2018 (#,*equal contribution)

Bauer C, Abdul Pari AA, Umansky V, Utikal J, Boukamp P, Augustin HG, Goerdt S, Géraud C, Felcht M. 2018. T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin. Cancer Immunol Immunother. 2018 Jul;67(7):1147-1157

Kober KI, Cano A, Géraud C, Sipilä K, Mobasseri SA, Philippeos C, Pisco AO, Stannard A, Martin A, Salvador F, Santos V, Boutros M, Rognoni E, Watt FM. 2018. Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation. PLoS One. 2018 Jun 28;13(6):e0199679. doi: 10.1371/journal.pone.0199679. eCollection 2018. PMID: 29953488

Hüser L, Sachindra, Granados K, Federico A, Larribère L, Novak D, Umansky V, Altevogt P, Utikal J, 2018. SOX2-mediated upregulation of CD24 promotes adaptive resistance towards targeted therapy in melanoma. Int J Cancer. 2018 Jun 15. doi: 10.1002/ijc.31609

Weber R, Fleming V, Hu X, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V. 2018. Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors. Front Immunol. 2018 Jun 11;9:1310. doi: 10.3389/fimmu.2018.01310. eCollection 2018. (Review)

Dix CL, Matthews HK, Uroz M, McLaren S, Wolf L, Heatley N, Win Z, Almada P, Henriques R, Boutros M, Trepat X, Baum B. 2018. The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division. Dev Cell. 2018 Apr 9;45(1):132-145.e3. doi: 10.1016/j.devcel.2018.03.009

Fleming V, Hu X, Weber R, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V. 2018. Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression. Front Immunol. 2018 Mar 2;9:398. doi: 10.3389/fimmu.2018.00398. eCollection 2018. (Review)

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG., Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS. 2018. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1

Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS. 2018. GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro. Biochem Biophys Res Commun. 2018 Feb 26;497(1):32-38. doi: 10.1016/j.bbrc.2018.01.185. Epub 2018 Feb 1

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, et al. CCR5 + Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res 2018 Jan 1; 78 (1):157–167. doi:10.1158/0008-5472.CAN-17-0348


Dollt C, Becker K, Michel J, Melchers S,  Weis CA, Schledzewski K, Krewer A, Kloss L, Gebhardt C, Utikal J, Schmieder A, 2017. The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation. Oncotarget. 8:103682–103692. doi: 10.18632/oncotarget.21771

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen S, Pihlajaniemi T, Arnold B, Rodewald H, Augustin HG, Schledzewski K, Goerdt S, 2017. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 127:1099-1114. doi: 10.1172/JCI90086.

Horn S, Hughes MA, Schilling R, Sticht C, Tenev T, Ploesser M, Sprick MR, Meier P, MacFarlane M, Leverkus M, 2017. Caspase-10 Negatively Regulates Caspase-8- Mediated Cell Death, Switching the Response to CD95L in Favor of NF- k B Activation and Cell Survival. Cell Reports 19:785–797. doi:10.1016/j.celrep.2017.04.010

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S, Géraud C, 2017. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129:415–420. doi:10.1182/blood-2016-07-729822

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG., Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS, 2017. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantz H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS, 2017.  GATA4 and LMO3 balance angiocrine signalling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 5;627:491-499. doi: 10.1016/j.gene.2017.06.051

Sachindra, Larribère L, Novak D, Wu H, Hüser L, Granados K, Orouji E, Utikal J, 2017. New role of ID3 in melanoma adaptive drug-resistance. Oncotarget. 8:110166–110175. doi: 10.18632/oncotarget.22698
12.    Sedlmeier, G, Sleeman JP, 2017. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem. Soc. Trans. 45:173–181. doi:10.1042/BST20160263


Goertz L*, Schneider SW*, Desch A, Mayer FT, Koett J, Nowak K, Karampinis I, Bohlmann MK, Umansky V, Bauer AT, 2016. Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget 7:68527–45. doi:10.18632/oncotarget.11832

Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JWR, Leverkus M, Cain K, MacFarlane M, 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol. Cell 61:834–849. doi:10.1016/j.molcel.2016.02.023

Krachulec JM, Sedlmeier G, Thiele W, Sleeman JP, 2016. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem. Cell Biol. 94:289–96. doi:10.1139/bcb-2015-0150

Weina K*, Wu H*, Knappe N, Orouji E, Novak D, Bernhardt M, Hüser L, Larribère L, Umansky V, Gebhardt C, Utikal J, 2016. TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells. Pigment Cell Melanoma Res. 29:453–458. doi:10.1111/pcmr.12483

Publications by Associated PhD and MD of the RTG since 2015


Jäger K*, Larribère L*, Wu H, Weiss C, Gebhardt C, Utikal J. Expression of Neural Crest Markers GLDC and ERRFI1 is Correlated with Melanoma Prognosis. Cancers (Basel). 2019, 11 (1), 76; doi: 10.3390/cancers11010076

Fleming V, Umansky V, 2018. Two MDSC faces in obesity: Correcting metabolic dysfunctions but promoting tumor development. J Leukoc Biol. 103:373-375. doi: 10.1002/JLB.3CE1017-416R.

Huber V, Vallacchi V, Fleming V, Hu X, Cova A, Dugo M, Shahaj E, Sulsenti R, Vergani E, Filipazzi P, De Laurentiis A, Lalli L, Di Guardo L, Patuzzo R, Vergani B, Casiraghi E, Gualeni A, Bollati V, Arienti F, Mariani L, Villa A, Altevogt P, Umansky V, Rodolfo M, Rivoltini L. MDSC-miRs convey immune suppressive properties to monocytes in melanoma. J Clin Invest, 2018 Nov 5. pii: 98060. doi: 10.1172/JCI98060.

Sharbi-Yunger A, Grees M, Gal C, Bassan D, Eichmüller SB, Tzehoval E, Utikal J, Umansky V, Eisenbach L. 2018. A universal anti-cancer vaccine: Chimeric invariant chain potentiates the inhibition of melanoma progression and the improvement of survival. Int J Cancer. 2018 Aug 14. doi: 10.1002/ijc.31795.

Umansky V, Adema GJ, Baran J., Brandau S., Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG. 2018. Interactions among myeloid regulatory cells in cancer. Cancer Immunol Immunother. Epub 2018 Jul 12. doi: 10.1007/s00262-018-2200-6.

Wu H, Larribère L, Sun Q, Novak D, Sachindra S, Granados K, Umansky V, Utikal J. 2018. Loss of neural crest-associated gene FOXD1 impairs melanoma invasion and migration via RAC1B downregulation. Int J Cancer. 2018 Aug 15. doi: 10.1002/ijc.31799.

Yamauchi Y, Safi S, Blattner C, Rathinasamy A, Umansky L, Juenger S, Warth A, Eichhorn M, Muley T, Herth FJF, Dienemann H, Platten M, Beckhove P, Utikal J, Hoffmann H, Umansky V, 2018. Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-small-cell Lung Cancer. Am J Respir Crit Care Med. 2018 in press.

Grees M, Sharbi-Yunger A, Evangelou C, Baumann D, Cafri G, Tzehoval E, Eichmüller SB, Offringa R, Utikal J, Eisenbach L, Umansky V. 2018. Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models. Oncoimmunology. 2018 Mar 26;7(7):e1445457. doi: 10.1080/2162402X.2018.1445457. eCollection 2018


Baum C, Weiss C, Gebhardt C, Utikal J, Marx A, Koenen W, Géraud C, 2017. Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. Int J Cancer 140:1907–1917. doi:10.1002/ijc.30563

Desch A, Gebhardt C, Utikal J, Schneider SW, 2017. D-dimers in malignant melanoma: Association with prognosis and dynamic variation in disease progress. Int J Cancer 140:914-921 doi:10.1002/ijc.30498

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N, 2017. CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development. Cell Rep. 21:2212-2222. doi: 10.1016/j.celrep.2017.10.104.

Umansky V, Blattner C, Gebhardt C, Utikal J, 2017. CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma. Cancer Immunol Immunother. 2017 Aug;66(8):1015-1023. doi: 10.1007/s00262-017-1988-9.

Umansky V, Blattner C, Fleming V, Hu X, Gebhardt C, Altevogt P, Utikal J, 2017. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin Immunopathol. 39:295-305.


Fehrenbach S, Novak D, Bernhardt M, Larribere L, Boukamp P, Umansky V, Utikal J, 2016. Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci Rep 6:1–12. doi:10.1038/srep28891

Jacquelot N, Enot DP, Flament C, Vimond N, Blattner C, Pitt JM, Yamazaki T, Roberti MP, Daillère R, Vétizou M, Poirier-Colame V, Semeraro M, Caignard A, Slingluff CL Jr, Sallusto F, Rusakiewicz S, Weide B, Marabelle A, Kohrt H, Dalle S, Cavalcanti A, Kroemer G, Di Giacomo AM, Maio M, Wong P, Yuan J, Wolchok J, Umansky V, Eggermont A, Zitvogel L, 2016. Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma. J Clin Invest. 126:921-37. doi: 10.1172/JCI80071.

Tähtinen S, Blattner C, Vähä-Koskela M, Saha D, Siurala M, Parviainen S, Utikal J, Kanerva A, Umansky V, Hemminki A, 2016. T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma. J Immunother. 39:343-354.

Umansky, V, Blattner, C, Gebhardt, C, Utikal, J, 2016. The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression. Vaccines 4. doi:10.3390/vaccines4040036


Bauer AT*, Suckau J*, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-valdes N, Umansky V, Schneider SW, 2015. von Willebrand factor fi bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood 125:3153–3164. doi:10.1182/blood-2014-08-595686.A.T.B.

Most Important Publications of the PIs of the RTG since 2015

Ni J, Wang X, Stojanovic A, Zhang Q, Wincher M, Bühler L, Arnold A, Correia MP, Winkler M, Koch PS, Sexl V, Höfer T, Cerwenka A. Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity. Immunity. 2020 Jun 16;52(6):1075-1087.e8. doi: 10.1016/j.immuni.2020.05.001. Epub 2020 May 22.

La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HC, Savant S, Augustin HG: Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest, 128:834-845, 2018

Augustin HG, Koh GY: Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology. Science, 357. pii: eaal2379, 2017

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls vessel maturation. Nat Commun. 8:16106, 2017.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca(2+)/NFAT signaling. Dev Cell, 36: 79-93, 2016.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells. Cell Rep, 12: 1761-73, 2015. 

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M: Toward an integrated map of genetic interactions in cancer cells. Mol Syst Biol, 14:e7656, 2018

Boutros M, Heigwer F, Laufer C. Microscopy-Based High-Content Screening. Cell, 163:1314-25, 2015

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A. Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol, 68:421-430, 2018

Granzin M, Stojanovic A, Miller M, Childs R, Huppert V, Cerwenka A. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma. Oncoimmunology, 5:e1219007, 2016

Natural killer cell memory in infection, inflammation and cancer. Cerwenka A, Lanier LL. Nat Rev Immunol, 16:112-23, 2016

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127: 1099-114, 2017.

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129: 415-9, 2017 (*equal contribution).

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V. CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res, 78:157-167, 2018

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun, 7:12150, 2016

Gebhardt C, Sevko A, Jiang H, Lichtenberger R, Reith M, Tarnanidis K, Holland-Letz T, Umansky L, Beckhove P, Sucker A, Schadendorf D, Utikal J, Umansky V. Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab. Clin Cancer Res, 21:5453-9, 2015

Hassel JC, Jiang H, Bender C, Winkler J, Sevko A, Shevchenko I, Halama N, Dimitrakopoulou-Strauss A, Haefeli WE, Jäger D, Enk A, Utikal J, Umansky V. Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe). Oncoimmunology, 6:e1326440, 2017.

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Doctoral Theses (Doctoral Researchers funded by the RTG)

PhD Theses

Dr. Lucie Wolf
Ubiquitin-dependent regulation of the WNT cargo protein EVI/WLS

Dr. Rebekka Weber
Regulation of CCR5 expression and immunosuppressive phenotype of MDSC in melanoma

Dr. Felix Funck
Innate immune cell crosstalk induces melanoma cell senescence

Dr. José Robador Arteta
Crosstalk between melanoma cells and the blood-brain barrier: impact on coagulation and brain metastasis to identify new anti-metastatic targets

Dr. Melanie Schwab
Function of the mucin-like glycoprotein Podoplanin in the progression of cutaneous squamous cell carcinoma

Dr. Florian Köhler
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria Syndrome

Dr. Katharina Kober
Elucidating the role of Wnt secretion in cutaneous squamous cell carcinoma (cSCC)

Dr. Loreen Kloss
Molecular and Functional Characterization of P2Y12 Expression in Tumor-associated Macrophages

Dr. Federico Aniello
Molecular and functional characterization of the role of the histone methyltransferase SETDB1 in malignant melanoma

Dr. Diego Martin Garcia
Characterization and modulation of CC-chemokine receptor 6 (CCR6)-mediated immune-surveillance in malignant melanoma

Dr. Georg Sedlmeier
The role of ld proteins in determining the tumor initiating and metastatic properties of melanoma cells

Dr. Johanna Zierow
Investigation of liver sinusoidal endothelial cells – Characterisation and application of new transgenic mouse models

Dr. Laura Hüser
The role of SOX2 in resistance towards targeted therapy

Dr. Ramon Schilling
Identification and characterisation of novel components involved in Ripoptosome mediated signal transduction

Dr. Sebastian Horn
Die Rolle der Caspase-10 in der Zelltodresistenz des malignen Melanoms

MD Theses

Dr. Thomas Leibing
Angiokrine Liganden des Wnt Signalwegs kontrollieren die Lebergröße und die metabolische Zonierung der Hepatozyten in Mäusen

Dr. Christian Schmid
Zelltypspezifische Charakterisierung des humanen G-Protein-gekoppelten Rezeptors 182 (GPR182)

Doctoral Theses (Doctoral Researchers funded by other sources)

PhD Theses

Dr. Karol Granados Blanco
Partial reprogramming – a model for melanoma targeted therapy resistance

Dr. Xiaoying Hu
Role of tumor-derived extracellular vesicles in immunosuppression in malignant melanoma patients

Dr. Viktor Fleming
Role of tumor-derived exosomes in the induction of immunosuppression in melanoma

Dr. Carolin Blattner
The Role of CCR5 in the Recruitment of MDSC to the Tumor Microenvironment

Dr. Claudia Dollt
Analysis of the Relevance of LYVE-1+ Tumor-associated Macrophages of Melanoma.

Dr. Sabrina Fehrenbach
Loss of tumorigenicity by transdifferentiation: from squamous cell carcinoma to melanocyte-like cells.

Dr. Mareike Grees
Improved dendritic cell vaccination for combined melanoma immune therapy

Dr. Lisa Schardt
The impact of Cyclosporine A on human epidermal keratinocytes

Dr. Huizi Wu
The role of neural crest specific genes in melanoma pathogenesis

MD Theses

To date no MD theses have been completed.