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Publications & Theses

Publications

Publications by PhD and MD students of the RTG 2099 since 2015

2018

Blattner C, Fleming V, Weber R, Himmelhan BS, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V, 2018. CCR5+ myeloid-derived suppressor cells are enriched and activated in melanoma lesions. Cancer Res. 78:157-167.

Fleming V, Hu X, Weber R, Nagibin V, Groth C, Altevogt P, Utikal J, Umansky V, 2018 Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression. Front Immunol. 9:398. doi: 10.3389/fimmu.2018.00398. eCollection 2018.

Hüser L, Sachindra, Granados K, Federico A, Larribère L, Novak D, Umansky V, Altevogt P, and Utikal J (2018) SOX2-mediated upregulation of CD24 promotes adaptive resistance towards targeted therapy in melanoma. Int J Cancer, in press

Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS, 2018. Biochem Biophys Res Commun. 497:32-38. doi: 10.1016/j.bbrc.2018.01.185

2017

Dollt C, Becker K, Michel J, Melchers S,  Weis CA, Schledzewski K, Krewer A, Kloss L, Gebhardt C, Utikal J, Schmieder A, 2017. The shedded ectodomain of Lyve-1 expressed on M2-like tumor-associated macrophages inhibits melanoma cell proliferation. Oncotarget. 8:103682–103692. doi: 10.18632/oncotarget.21771

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen S, Pihlajaniemi T, Arnold B, Rodewald H, Augustin HG, Schledzewski K, Goerdt S, 2017. GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 127:1099-1114. doi: 10.1172/JCI90086.

Horn S, Hughes MA, Schilling R, Sticht C, Tenev T, Ploesser M, Sprick MR, Meier P, MacFarlane M, Leverkus M, 2017. Caspase-10 Negatively Regulates Caspase-8- Mediated Cell Death, Switching the Response to CD95L in Favor of NF- k B Activation and Cell Survival. Cell Reports 19:785–797. doi:10.1016/j.celrep.2017.04.010

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S, Géraud C, 2017. Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129:415–420. doi:10.1182/blood-2016-07-729822

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG., Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS, 2017. Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology. 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]

Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantz H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS, 2017.  GATA4 and LMO3 balance angiocrine signalling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 5;627:491-499. doi: 10.1016/j.gene.2017.06.051

Sachindra, Larribère L, Novak D, Wu H, Hüser L, Granados K, Orouji E, Utikal J, 2017. New role of ID3 in melanoma adaptive drug-resistance. Oncotarget. 8:110166–110175. doi: 10.18632/oncotarget.22698
12.    Sedlmeier, G, Sleeman JP, 2017. Extracellular regulation of BMP signaling : welcome to the matrix. Biochem. Soc. Trans. 45:173–181. doi:10.1042/BST20160263

2016

Goertz L*, Schneider SW*, Desch A, Mayer FT, Koett J, Nowak K, Karampinis I, Bohlmann MK, Umansky V, Bauer AT, 2016. Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis. Oncotarget 7:68527–45. doi:10.18632/oncotarget.11832

Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JWR, Leverkus M, Cain K, MacFarlane M, 2016. Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate. Mol. Cell 61:834–849. doi:10.1016/j.molcel.2016.02.023

Krachulec JM, Sedlmeier G, Thiele W, Sleeman JP, 2016. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem. Cell Biol. 94:289–96. doi:10.1139/bcb-2015-0150

Weina K*, Wu H*, Knappe N, Orouji E, Novak D, Bernhardt M, Hüser L, Larribère L, Umansky V, Gebhardt C, Utikal J, 2016. TGF-β induces SOX2 expression in a time-dependent manner in human melanoma cells. Pigment Cell Melanoma Res. 29:453–458. doi:10.1111/pcmr.12483

Publications by Associated PhD and MD of the RTG since 2015

2018

Fleming V, Umansky V, 2018. Two MDSC faces in obesity: Correcting metabolic dysfunctions but promoting tumor development. J Leukoc Biol. 103:373-375. doi: 10.1002/JLB.3CE1017-416R.

Yamauchi Y, Safi S, Blattner C, Rathinasamy A, Umansky L, Juenger S, Warth A, Eichhorn M, Muley T, Herth FJF, Dienemann H, Platten M, Beckhove P, Utikal J, Hoffmann H, Umansky V, 2018. Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-small-cell Lung Cancer. Am J Respir Crit Care Med. 2018 in press.

2017

Baum C, Weiss C, Gebhardt C, Utikal J, Marx A, Koenen W, Géraud C, 2017. Sentinel node metastasis mitotic rate (SN-MMR) as a prognostic indicator of rapidly progressing disease in patients with sentinel node-positive melanomas. Int J Cancer 140:1907–1917. doi:10.1002/ijc.30563

Desch A, Gebhardt C, Utikal J, Schneider SW, 2017. D-dimers in malignant melanoma: Association with prognosis and dynamic variation in disease progress. Int J Cancer 140:914-921 doi:10.1002/ijc.30498

Hawila E, Razon H, Wildbaum G, Blattner C, Sapir Y, Shaked Y, Umansky V, Karin N, 2017. CCR5 Directs the Mobilization of CD11b+Gr1+Ly6Clow Polymorphonuclear Myeloid Cells from the Bone Marrow to the Blood to Support Tumor Development. Cell Rep. 21:2212-2222. doi: 10.1016/j.celrep.2017.10.104.

Umansky V, Blattner C, Gebhardt C, Utikal J, 2017. CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma. Cancer Immunol Immunother. 2017 Aug;66(8):1015-1023. doi: 10.1007/s00262-017-1988-9.

Umansky V, Blattner C, Fleming V, Hu X, Gebhardt C, Altevogt P, Utikal J, 2017. Myeloid-derived suppressor cells and tumor escape from immune surveillance. Semin Immunopathol. 39:295-305.

2016

Fehrenbach S, Novak D, Bernhardt M, Larribere L, Boukamp P, Umansky V, Utikal J, 2016. Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci Rep 6:1–12. doi:10.1038/srep28891

Jacquelot N, Enot DP, Flament C, Vimond N, Blattner C, Pitt JM, Yamazaki T, Roberti MP, Daillère R, Vétizou M, Poirier-Colame V, Semeraro M, Caignard A, Slingluff CL Jr, Sallusto F, Rusakiewicz S, Weide B, Marabelle A, Kohrt H, Dalle S, Cavalcanti A, Kroemer G, Di Giacomo AM, Maio M, Wong P, Yuan J, Wolchok J, Umansky V, Eggermont A, Zitvogel L, 2016. Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma. J Clin Invest. 126:921-37. doi: 10.1172/JCI80071.

Tähtinen S, Blattner C, Vähä-Koskela M, Saha D, Siurala M, Parviainen S, Utikal J, Kanerva A, Umansky V, Hemminki A, 2016. T-Cell Therapy Enabling Adenoviruses Coding for IL2 and TNFα Induce Systemic Immunomodulation in Mice With Spontaneous Melanoma. J Immunother. 39:343-354.

Umansky, V, Blattner, C, Gebhardt, C, Utikal, J, 2016. The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression. Vaccines 4. doi:10.3390/vaccines4040036

2015

Bauer AT*, Suckau J*, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-valdes N, Umansky V, Schneider SW, 2015. von Willebrand factor fi bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans. Blood 125:3153–3164. doi:10.1182/blood-2014-08-595686.A.T.B.

Most Important Publications of the PIs of the RTG since 2015

La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HC, Savant S, Augustin HG: Tie1–mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest, 128:834-845, 2018

Augustin HG, Koh GY: Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology. Science, 357. pii: eaal2379, 2017

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls vessel maturation. Nat Commun. 8:16106, 2017.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca(2+)/NFAT signaling. Dev Cell, 36: 79-93, 2016.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells. Cell Rep, 12: 1761-73, 2015. 

Rauscher B, Heigwer F, Henkel L, Hielscher T, Voloshanenko O, Boutros M: Toward an integrated map of genetic interactions in cancer cells. Mol Syst Biol, 14:e7656, 2018

Boutros M, Heigwer F, Laufer C. Microscopy-Based High-Content Screening. Cell, 163:1314-25, 2015

Pollmann J, Götz JJ, Rupp D, Strauss O, Granzin M, Grünvogel O, Mutz P, Kramer C, Lasitschka F, Lohmann V, Björkström NK, Thimme R, Bartenschlager R, Cerwenka A. Hepatitis C virus-induced natural killer cell proliferation involves monocyte-derived cells and the OX40/OX40L axis. J Hepatol, 68:421-430, 2018

Granzin M, Stojanovic A, Miller M, Childs R, Huppert V, Cerwenka A. Highly efficient IL-21 and feeder cell-driven ex vivo expansion of human NK cells with therapeutic activity in a xenograft mouse model of melanoma. Oncoimmunology, 5:e1219007, 2016

Natural killer cell memory in infection, inflammation and cancer. Cerwenka A, Lanier LL. Nat Rev Immunol, 16:112-23, 2016

Leibing T*, Géraud C*, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 2017 Oct 23. doi: 10.1002/hep.29613. [Epub ahead of print]

Géraud C*, Koch PS*, Zierow J*, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin H, Schledzewski K, Goerdt S: Gata4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopopiesis. J Clin Invest, 127: 1099-114, 2017.

Koch PS*, Olsavszky V*, Ulbrich F, Sticht C, Demory A, Leibing T, Henzler T, Meyer M, Zierow J, Schneider S, Breitkopf-Heinlein K, Gaitantzi H, Spencer-Dene B, Arnold B, Klapproth K, Schledzewski K, Goerdt S*, Géraud C*: Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129: 415-9, 2017 (*equal contribution).

Blattner C, Fleming V, Weber R, Himmelhan B, Altevogt P, Gebhardt C, Schulze TJ, Razon H, Hawila E, Wildbaum G, Utikal J, Karin N, Umansky V. CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res, 78:157-167, 2018

Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, Mandruzzato S, Murray PJ, Ochoa A, Ostrand-Rosenberg S, Rodriguez PC, Sica A, Umansky V, Vonderheide RH, Gabrilovich DI. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun, 7:12150, 2016

Gebhardt C, Sevko A, Jiang H, Lichtenberger R, Reith M, Tarnanidis K, Holland-Letz T, Umansky L, Beckhove P, Sucker A, Schadendorf D, Utikal J, Umansky V. Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab. Clin Cancer Res, 21:5453-9, 2015

Hassel JC, Jiang H, Bender C, Winkler J, Sevko A, Shevchenko I, Halama N, Dimitrakopoulou-Strauss A, Haefeli WE, Jäger D, Enk A, Utikal J, Umansky V. Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe). Oncoimmunology, 6:e1326440, 2017.

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A. Endothelial Notch1 Activity Facilitates Metastasis. Cancer Cell, 31:355-367, 2017

Osswald M, Blaes J, Liao Y, Solecki G, Gömmel M, Berghoff AS, Salphati L, Wallin JJ, Phillips HS, Wick W, Winkler F. Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases. Clin Cancer Res, 22:6078-6087, 2016

Osswald M, Jung E, Sahm F, Solecki G, Venkataramani V, Blaes J, Weil S, Horstmann H, Wiestler B, Syed M, Huang L, Ratliff M, Karimian Jazi K, Kurz FT, Schmenger T, Lemke D, Gömmel M, Pauli M, Liao Y, Häring P, Pusch S, Herl V, Steinhäuser C, Krunic D, Jarahian M, Miletic H, Berghoff AS, Griesbeck O, Kalamakis G, Garaschuk O, Preusser M, Weiss S, Liu H, Heiland S, Platten M, Huber PE, Kuner T, von Deimling A, Wick W, Winkler F. Brain tumour cells interconnect to a functional and resistant network. Nature, 528:93-8, 2015

Doctoral Theses (Doctoral Researchers funded by the RTG)

PhD Theses

Dr. Sebastian Horn
Die Rolle der Caspase-10 in der Zelltodresistenz des malignen Melanoms

Dr. Laura Hüser
The role of SOX2 in resistance towards targeted therapy

Dr. Ramon Schilling
Identification and characterisation of novel components involved in Ripoptosome mediated signal transduction

Dr. Johanna Zierow
Investigation of liver sinusoidal endothelial cells – Characterisation and application of new transgenic mouse models

MD Theses

To date no MD theses have been completed.  

Doctoral Theses (Doctoral Researchers funded by other sources)

PhD Theses

Dr. Carolin Blattner
The Role of CCR5 in the Recruitment of MDSC to the Tumor Microenvironment

Dr. Claudia Dollt
Analysis of the Relevance of LYVE-1+ Tumor-associated Macrophages of Melanoma.

Dr. Sabrina Fehrenbach
Loss of tumorigenicity by transdifferentiation: from squamous cell carcinoma to melanocyte-like cells.

Dr. Mareike Grees
Improved dendritic cell vaccination for combined melanoma immune therapy

Dr. Lisa Schardt
The impact of Cyclosporine A on human epidermal keratinocytes

Dr. Huizi Wu
The role of neural crest specific genes in melanoma pathogenesis

MD Theses

To date no MD theses have been completed.  

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