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PhD Students
Dennis Agardy
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg
d.agardy@dkfz.de
Thesis: "Response and resistance to checkpoint blockade in melanoma brain metastases"
Project No. 14: "Response and Resistance to Checkpoint Blockade in melanoma brain metastases"
Lea Gärtner
Microvascular Biology and Pathobiology, Medical Faculty Mannheim, Heidelberg University
lea.gaertner@medma.uni-heidelberg.de
Thesis: "Novel inhibitors of the transcriptional regulators Id1 and Id3, and their potential for the treatment of melanoma“
Project No. 3: "The role of systemic osteopontin and senescence in melanoma metastasis and therapy resistance”
Denise Grieshober
Vascular Oncology and Metastasis, DKFZ, Heidelberg
d.grieshober@dkfz-heidelberg.de
Thesis: "The role of N-Fragment of Angiopoietin-like 4 during malignant melanoma
metastasis formation"
Project No. 4: "The role of N-Fragment of Angiopoietin-like 4 during malignant melanoma metastasis formation"
Verena Häfele
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
verena.haefele@medma.uni-heidelberg.de
Thesis: "Liver-specific endothelial mechanism of melanoma metastasis"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Marvin Hering
T Cell Metabolism (D140), DKFZ, Heidelberg
m.hering@dkfz-heidelberg.de
Thesis: "Regulation of anti-tumor immune responses by nutrient availability in melanoma"
Project No. 15: "Regulation of anti-tumor immune responses by nutrient availability in melanoma"
Johannes Hoffmann
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
johannes.hoffmann@medma.uni-heidelberg.de
Thesis: "Endotheliale Regulation der Metastasierung in Lymphknoten, Leber und Knochen"
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Tomas Hofman
Immunobiochemistry, Medical Faculty Mannheim, Heidelberg University
tomas.hofman@medma.uni-heidelberg.de
Thesis: "Defining innate immune checkpoints controlling NK cell recognition of melanoma cells”
Project No. 9: "Defining innate immune checkpoints controlling Natural Killer cell recognition of melanoma cells"
Samantha Lasser
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
samantha.Lasser@medma.uni-heidelberg.de
Thesis: "Stimulation of myeloid cell-mediated immunosuppression via TLR signaling and its targeting in melanoma"
Project No. 11: "Stimulation of myeloid cell-mediated immunosuppression via TLR signaling and its targeting in melanoma"
Iris Müller
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
iris.mueller@medma.uni-heidelberg.de
Thesis: „Inhibiting glucocorticoid receptor signaling in tumor-associated macrophages for antitumor immune response“
Project No. 10: "Role of the glucocorticoid-induced P2Y12/P2Y14+ G-protein coupled receptors for TAM in melanoma"
Siuwang Ng
Signaling and functional genomics (B110), DKFZ, Heidelberg
s.ng@dkfz-heidelberg.de
Thesis: "Dissecting the role of Wnt signaling in melanoma"
Project No. 1: "Dissecting the role of Wnt signaling in melanoma"
Sandra Pardo Valencia
Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg
sandra.pardovalencia@dkfz-heidelberg.de
Thesis: "Generation of T cells from iPS cells for melanoma treatment"
Project No. 13: "Differentiation of induced pluripotent stem cells into tumor antigen-specific T cells for melanoma immunotherapy"
Rafael Saup
Microvascular Biology and Pathobiology, Medical Faculty Mannheim, Heidelberg University
rafael.saup@medma.uni-heidelberg.de
Thesis: "Cell-intrinsic and mircoenvironmental control of melanoma metastasis and therapy resistance”
Project No. 3: "The role of systemic osteopontin and senescence in melanoma metastasis and therapy resistance”
Julia Schüler
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
julia.schueler@medma.uni-heidelberg.de
Thesis: „Zur Analyse von angiokrinen und pro-adhäsiven Faktoren in der hepatischen vaskulären Nische im Rahmen der Lebermetastasierung des Malignen Melanoms“
Project No. 6: "Role of YAP/TAZ in the endothelium of melanoma brain metastasis“
Saskia Tauch
Division Signal Transduction and Growth Control, DKFZ, Heidelberg
s.tauch@dkfz-heidelberg.de
Thesis: "Communication between tumor cells and fibroblasts in the tumor microenvironment during melanoma progression"
Project No. 2: "Communication between tumor cells and fibroblasts in the tumor microenvironment during melanoma progression"
Céline Weller
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
celine.weller@medma.uni-heidelberg.de
Thesis: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Melanie Wiecken
Section of Dermatological Oncology, Dept. Dermatology, University Medical Center Heidelberg, and National Center of Tumor Diseases (NCT)
melanie.wiecken@uni-heidelberg.de
Thesis: "The role of the immune checkpoints LAG-3 and TIM-3 in melanoma"
Project No. 12: "The role of the immune checkpoints LAG-3 and TIM-3 for immunotherapy of melanoma"
MD Students
Ihor Arkhypov
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
ihor.arkhypov@medma.uni-heidelberg.de
Thesis: "Role of tumor-derived exosomes in induction of immunosuppressive myeloid cells in melanoma patients"
Project No. 11: "Stimulation of myeloid cell-mediated immunosuppression via TLR signaling and its targeting in melanoma"
Tinja Baljkas
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
tinja.baljkas@medma.uni-heidelberg.de
Thesis: „Zur Rolle des Transkriptionsfaktors GATA-4 und assoziierter Signalwege im Lebersinusendothel bei der Entstehung der Leberfibrose“
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Anja Gampp
Vascular Oncology and Metastasis, DKFZ, Heidelberg
anja.gampp@nct-heidelberg.de
Thesis: "Die epigenetische Reprogrammierung von Endothelzellen während des Metastasierungsprozesses"
Project No. 4: "The role of N-Fragment of Angiopoietin-like 4 during malignant melanoma metastasis formation"
Julia Gellert
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg
julia.gellert@dkfz-heidelberg.de
Thesis: “Characterization of the melanoma-specific T cell response in the CNS tumor microenvironment under immunotherapy“
Project No. 14: "Response and resistance to checkpoint blockade in melanoma brain metastases"
Nils Hebach
Clinical Cooperation Unit Neuro-Oncology, DKFZ, Heidelberg
nils.hebach@dkfz-heidelberg.de
Thesis: „T cell homing and microenvironmental cues in melanoma brain metastasis“
Project No. 7: "Mechanisms of T cell homing and function in melanoma brain metastases"
Joschka Heil
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
joschka.heil@medma.uni-heidelberg.de
Thesis: "Einfluss von endothelialer β-Catenin Aktivierung auf die Stammzell-Nische im Knochenmark"
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Katharina Held
Microvascular Biology and Pathobiology, Medical Faculty Mannheim, Heidelberg University
katharina.held@medma.uni-heidelberg.de
Thesis: "Erforschung der molekularen Mechanismen der Resistenzenbildung von Melanomen gegen kombinierte Therapie mit BRAF- und MEK-Inhibitoren"
Project No. 3: "The role of systemic osteopontin and senescence in melanoma metastasis and therapy resistance"
Anna Lena Irkens
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
anna.Irkens@medma.uni-heidelberg.de
Thesis: „Mechanismen und therapeutische Modulation der Stabilin-mediierten Scavengingfunktion bei der hepatischen Melanommetastasierung“
Project No. 8: “Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Anna Jauch
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
anna.jauch@medma.uni-heidelberg.de
Thesis: "Bedeutung von LYVE1 in der hepatischen vaskulären Nische für die Melanom-metastasierung in die Leber"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Niklas Kehl
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg
niklas.kehl@dkfz-heidelberg.de
Thesis: "Establishment of a preclinical adoptive transfer model against immunogenic gene fusions"
Project No. 14: "Response and resistance to checkpoint blockade in melanoma brain metastases"
Christof Kirkamm
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
christof.kirkamm@medma.uni-heidelberg.de
Thesis: "Biochemical and functional characterization of potential ligands of Stabilin-1 and Stabilin-2"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Philipp Koopmann
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKFZ, Heidelberg
philipp.koopmann@dkfz-heidelberg.de
Thesis: „Identifikation und Charakterisierung tumorreaktiver T-Zellen in Hirnmetastasen“
Project No. 14: "Response and resistance to checkpoint blockade in melanoma brain metastases"
Alisa Lepper
Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg
alisa.lepper@dkfz-heidelberg.de
Thesis: "Das Verhalten von myeloid-derived suppressor cells (MDSCs) und T-Zellen bei Melanompatienten mit autoimmunen Nebenwirkungen unter Immuncheckpoint-Inhibitor Therapie"
Project No. 13: "Differentiation of induced pluripotent stem cells into tumor antigen-specific T cells for melanoma immunotherapy"
Marcel Müller
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
marcel.mueller@medma.uni-heidelberg.de
Thesis: "Die Rolle des Glukokortikoid-Rezeptors auf myeloiden Zellen in der Wundheilung"
Project No. 10: "Role of the glucocorticoid-induced P2Y12/P2Y14+ G-protein coupled receptors for TAM in melanoma"
Ana Olsavszky
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
ana.olsavszky@medma.uni-heidelberg.de
Thesis: "Bedeutung der hepatischen vaskulären Nische bei der Melanommetastasierung"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Vera Petrova
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
vera.petrova@medma.uni-heidelberg.de
Thesis: "The immuno-suppressive capacity of different subsets of myeloid-derived suppressor cells (MDSC) in melanoma patients under targeted immunotherapies"
Project No. 11: "Stimulation of myeloid cell-mediated immunosuppression via TLR signaling and its targeting in melanoma"
Kajetan Sandorski
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
kajetan.sandorski@medma.uni-heidelberg.de
Thesis: "Einfluss von konstitutiver beta-Catenin Aktivierung auf die Differenzierung von Lebersinusendothelzellen und die Metastasierung des Malignen Melanoms"
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Niklas Straub
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
niklas.straub@medma.uni-heidelberg.de
Thesis: "Influence of inflammatory monocytes and neutrophil granulocytes on hepatic melanoma metastasis“
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Maximilian Suhayda
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
maximilian.suhayda@medma.uni-heidelberg.de
Thesis: "Characterization of molecular co-regulators for hepatic vascular niche differentiation and liver function"
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Cedric Tehranian
Clinical Cooperation Unit Neuro-Oncology, DKFZ, Heidelberg
c.tehranian@dkfz-heidelberg.de
Thesis: "Targeting the P13K-AKT-mTor pathway in melanoma brain metastasis"
Project No. 7: "Mechanisms of T cell homing and function in melanoma brain metastases"
Yang Tuo
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
yang.tuo@medma.uni-heidelberg.de
Thesis: "Zur Rolle des Notch-Signalwegs im Lebersinusendothel bei der Entstehung der Leberfibrose"
Project No. 5: "The lymph node vascular niche in melanoma metastasis"
Associated PhD Students
Bianca Dietsch
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
bianca.dietsch@medma.uni-heidelberg.de
Thesis: "Tumorintrinsische Promotoren der hepatischen Metastasierung"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Feyza Gul Ozbay Kurt
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
feyza.kurt@medma.uni-heidelberg.de
Thesis: "Targeting myeloid cell-mediated immunosuppression in malignant melanoma"
Project No. 11: "Stimulation of myeloid cell-mediated immunosuppression via TLR signaling and its targeting in melanoma"
Theresa Staniczek
Department of Dermatology, Venereology and Allergology, UMM, Mannheim
theresa.staniczek@medma.uni-heidelberg.de
Thesis: "Endotheliale Regulation der Leberhomöostase und Hepatokarzinogenese"
Project No. 8: "Pre-metastatic and immunologic conditioning of the hepatic vascular niche during melanoma progression"
Tamara Steinfass
Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg
t.steinfass@dkfz-heidelberg.de
Thesis: "SETDB1 in Melanom-Therapie Resistenz"
Project No. 13: "Differentiation of induced pluripotent stem cells into tumor antigen-specific T cells for melanoma immunotherapy"
Yiman Wang
Clinical Cooperation Unit Dermato-Oncology, DKFZ, Heidelberg
yiman.wang@dkfz-heidelberg.de
Thesis: “Characterization and functional role of neural crest-associated genes involved in melanoma therapy-induced resistance”
Project No. 13: "Differentiation of induced pluripotent stem cells into tumor antigen-specific T cells for melanoma immunotherapy"