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Department of Neurology participates in graduate school InCheck
The Department of Neurology is involved with two projects in the new Research Training Group GRK2727 InCheck: “Innate Immune Checkpoints in Cancer and Tissue Damage” funded by the German Research Foundation. read more …
Insight into the pathology of IgG4-associated diseases
Single cell sequencing deciphers pathogenic immune cell interaction in inflammatory pseudotumors of the brain. A platform developed at the Department of Neurology at the University Medical Centre Mannheim and the German Cancer Research Center now provides surprising insights into the pathology of IgG4-associated diseases. read more …
Review of the final symposium & spring school of the Research Training Group 2350 in June 2021
From 7th to 10th June Ph.D. and M.D. candidates immersed themselves in a virtual event at the final symposium and spring school 2021 of the research training group 2350 on the Impact of Adverse Childhood Experiences on Psychosocial and Somatic Conditions across the Lifespan. read more …
How „paralyzed“ immune cells can be reactivated against brain tumors
Researchers discovered, that brain tumor cells carrying a certain but common mutation, reprogram invading immune cells and thereby suppress the body’s immune defense against the tumor. The research team also identified a way of reactivating the paralyzed immune system to fight the tumor and provide evidence that therapeutic vaccines or immunotherapies against brain tumors are more effective, if the suppressed immune system is simultaneously treated and thereby supported by pharmacological substances. read more …
Balancing neuronal activity
To process information in our brains, neurons produce brief electrical impulses, called action potentials, triggered from one highly specialized region at the cell’s axon, called the axon initial segment (AIS). Scientists from the Institute of Neuroanatomy at the Mannheim Center for Translational Neuroscience (MCTN), together with researchers from the Netherlands Institute for Neuroscience in Amsterdam and the University of Göttingen now show that the AIS surprisingly changes with experience: It shrinks with increasing experience and, vice versa, elongates when less input arrives in the brain. This reversible effect could contribute to balancing all neuronal activity generated within a distinct functional network in the brain. read more …
BMBF supported project Nphys (Magerl) 16GW0293
„Einfluss FKBP51-überinduzierender Genotypen auf Schmerzphänotypen und humane Schmerzplastizität“, 2020 – 2022
PerPain: New research consortium to improve treatment response of chronic musculoskeletal pain disorders through a personalized therapy approach
6th August 2020
With a budget of approx. 2,100,000€, the BMBF funds the new research consortium “Improving outcomes in chronic musculoskeletal pain through a personalized medicine approach using cross-illness multilevel assessments and mechanism-based interventions” that involves two groups at the Central Institute of Mental Health represented by the Institute of Cognitive and Clinical Neuroscience (Prof. Dr. Dr. h.c. Dr. h.c. Herta Flor and Dr. Martin Löffler as co-investigator) and the Department of Public Mental Health (Prof. Dr. Ulrich Reininghaus). read more...
Losing and Regaining Control over Drug Intake
6th August 2020
The German Research Foundation (DFG) funded the Collaborative Research Centre/Transregio 265 Losing and Regaining Control over Drug Intake: From Trajectories to Mechanisms to Interventions. The project aims to better understand, which mechanisms are responsible for people losing control over drug use. Therapies should be developed on this basis. The CIMH cooperates with the Charité - Universitätsmedizin Berlin and the Technische Universität Dresden, among others.
Psychophysics of Functional Neurological Symptoms and the Role of Emotional Regulation in their Development
6th August 2020
The German Research Foundation (DFG) is funding the project “Psychophysics of Functional Neurological Symptoms and the Role of Emotional Regulation in their Development”. The project is a cooperation of CIMH and UMM, led by Dr. Inga Niedtfeld and Dr. Valentin Held. Since functional neurological disorders affect an interface between neurology and psychology, this research project will investigate psychological mechanisms (emotion regulation) using experimental methods as well as classical neurological testing procedures (quantitative sensory testing, QST).
MCTN´s inaugural meeting
3rd July 2020
The MCTN's mission is to facilitate interaction and translation in neuroscience in Mannheim. To this end, the MCTN's inaugural meeting was held on Friday 3rd July 2020 in the Alte Brauerei in Mannheim, where the members of the MCTN and the focus area Translational Neurosciences discussed future goals and the establishment of the MCTN.