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  • Kroll lab

    2020

    Li X, Schmöhl F, Qi H, Bennewitz K, Tabler CT, Poschet G, Hell G, Volk N, Poth T, Hausser I, Morgenstern J, Fleming T, Nawroth PP, Kroll J. Regulation of gluconeogenesis by Aldo-Keto-Reductase 1a1b in zebrafish. iScience, 2020.

    doi: 10.1016/j.isci.2020.101763

    Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol, 2020.

    doi: 10.1016/j.redox.2020.101723

    Wiggenhauser LM, Qi H, Stoll SJ, Metzger L, Bennewitz K, Poschet G, Krenning G, Hillebrands JL, Hammes HP, Kroll J. Activation of retinal angiogenesis in hyperglycemic pdx1-/- zebrafish mutants. Diabetes, 2020.

    doi: 10.2337/db19-0873

    2019

    Lodd E, Wiggenhauser LM, Morgenstern J, Fleming TH, Poschet G, Büttner M, Tabler CT, Wohlfart DP, Nawroth PP, Kroll J. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight, 2019.

    doi: 10.1172/jci.insight.126154

    Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk T, Morgenstern J, Fleming T, Nawroth PP, Kroll J. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cellular and Molecular Life Sciences, 2019.

    doi: 10.1007/s00018-019-03127

    She J, Wu Y, Lou B, Lodd E, Klems A, Schmoehl F, Yuan Z, Noble FL, Kroll J. Genetic compensation by epob in pronephros development in epoa mutant zebrafish. Cell Cycle, 2019.

    doi: 10.1080/15384101.2019.1656019

    2018

    She J, Yuan Z, Wu Y, Chen J, Kroll J. Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Mol Metab, 2018.

    doi: 10.1016/j.molmet.2017.11.006

    2017

    Wiggenhauser LM, Kohl K, Dietrich N, Hammes HP, Kroll J. Studying diabetes through the eyes of a fish: Microdissection, visualization and analysis of the adult tg(fli:EGFP) zebrafish retinal vasculature. J Vis Exp, 2017.

    doi:10.3791/56674

    2015

    Schaeker K, Bartsch S, Patry C, Cramer-Stoll S, Hillebrands JL, Wieland T, Kroll J. The bipartite Rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem, 2015.

    doi: 10.1074/jbc.M114.633701

    Jörgens K, Stoll SJ, Pohl J, Fleming TH, Sticht C, Nawroth PP, Hammes HP, Kroll J. High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signalling cascade. Diabetes, 2015.

    doi: 10.2337/db14-0352

    2011

    Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res, 2011.

    doi: 10.1161/CIRCRESAHA.111.244095

    2010

    Epting D, Wendik B, Bennewitz K, Dietz CT, Driever W, Kroll J. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Circ Res, 2010.

    doi: 10.1161/CIRCRESAHA.109.213983

     

  • Dobreva lab

    2017

    Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “ Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.” J Clin Invest. 2017 Jun 1;127(6):2235-2248.

    doi: 10.1172/JCI88725

    Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G. “Isl2b regulates anterior second heart field development in zebrafish.” Sci Rep. 2017,7:41043.

    doi: 10.1038/srep41043

    2016

    Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G. “Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.” EMBO Mol Med. 2016, 8(12):1380-1389.

    doi: 10.15252/emmm.201606382

    2015

    Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99

    doi: 10.1016/j.stem.2015.08.007

    Dobreva G, Braun T. “The transcriptional landscape of regenerating newborn mouse hearts.” Circ Res 2015, 116(5):767-9

    doi: 10.1161/CIRCRESAHA

    Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M,  Moretti A. “Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity.” Stem Cells 2015, 33(4): 1113-1129

    doi: 10.1002/stem.1923

    Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK. “Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.” Cereb Cortex 2015, 25(10): 3406-19

    doi: 10.1093/cercor/bhu156

    2014

    Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.

    doi: 10.3389/fgene.2014.00019

    2013

    Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. “Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.” Circ Res 2013, 113(7):856-62

    doi: 10.1161/CIRCRESAHA.113.302035

    2012

    Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK. “A network of genetic repression and derepression specifies projection fates in the developing neocortex.” Proc Natl Acad Sci U S A 2012, 109(47):19071-8

    doi: 10.1073/pnas.1216793109