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- Kroll lab
2020
Li X, Schmöhl F, Qi H, Bennewitz K, Tabler CT, Poschet G, Hell G, Volk N, Poth T, Hausser I, Morgenstern J, Fleming T, Nawroth PP, Kroll J. Regulation of gluconeogenesis by Aldo-Keto-Reductase 1a1b in zebrafish. iScience, 2020. doi: 10.1016/j.isci.2020.101763
Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol, 2020. doi: 10.1016/j.redox.2020.101723
Wiggenhauser LM, Qi H, Stoll SJ, Metzger L, Bennewitz K, Poschet G, Krenning G, Hillebrands JL, Hammes HP, Kroll J. Activation of retinal angiogenesis in hyperglycemic pdx1-/- zebrafish mutants. Diabetes, 2020. doi: 10.2337/db19-0873
2019
Lodd E, Wiggenhauser LM, Morgenstern J, Fleming TH, Poschet G, Büttner M, Tabler CT, Wohlfart DP, Nawroth PP, Kroll J. The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight, 2019. doi: 10.1172/jci.insight.126154
Schmöhl F, Peters V, Schmitt CP, Poschet G, Büttner M, Li X, Weigand T, Poth T, Volk T, Morgenstern J, Fleming T, Nawroth PP, Kroll J. CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cellular and Molecular Life Sciences, 2019. doi: 10.1007/s00018-019-03127
She J, Wu Y, Lou B, Lodd E, Klems A, Schmoehl F, Yuan Z, Noble FL, Kroll J. Genetic compensation by epob in pronephros development in epoa mutant zebrafish. Cell Cycle, 2019. doi: 10.1080/15384101.2019.1656019
2018
She J, Yuan Z, Wu Y, Chen J, Kroll J. Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Mol Metab, 2018. doi: 10.1016/j.molmet.2017.11.006
2017
Wiggenhauser LM, Kohl K, Dietrich N, Hammes HP, Kroll J. Studying diabetes through the eyes of a fish: Microdissection, visualization and analysis of the adult tg(fli:EGFP) zebrafish retinal vasculature. J Vis Exp, 2017. doi:10.3791/56674
2015
Schaeker K, Bartsch S, Patry C, Cramer-Stoll S, Hillebrands JL, Wieland T, Kroll J. The bipartite Rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) protects endothelial cells from apoptosis in blood vessel development. J Biol Chem, 2015. doi: 10.1074/jbc.M114.633701
Jörgens K, Stoll SJ, Pohl J, Fleming TH, Sticht C, Nawroth PP, Hammes HP, Kroll J. High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signalling cascade. Diabetes, 2015. doi:10.2337/db14-0352
2011
Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res, 2011. doi:10.1161/CIRCRESAHA.111.244095
2010
Epting D, Wendik B, Bennewitz K, Dietz CT, Driever W, Kroll J. The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish. Circ Res, 2010. doi:10.1161/CIRCRESAHA.109.213983
- Dobreva lab
2017
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “ Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.” J Clin Invest. 2017 Jun 1;127(6):2235-2248. doi:10.1172/JCI88725
Witzel HR, Cheedipudi S, Gao R, Stainier DY, Dobreva G. “Isl2b regulates anterior second heart field development in zebrafish.” Sci Rep. 2017,7:41043. doi:10.1038/srep41043
2016
Mehta A, Cordero J, Dobersch S, Romero-Olmedo AJ, Savai R, Bodner J, Chao CM, Fink L, Guzmán-Díaz E, Singh I, Dobreva G, Rapp UR, Günther S, Ilinskaya ON, Bellusci S, Dammann RH, Braun T, Seeger W, Gattenlöhner S, Tresch A, Günther A, Barreto G. “Non-invasive lung cancer diagnosis by detection of GATA6 and NKX2-1 isoforms in exhaled breath condensate.” EMBO Mol Med. 2016, 8(12):1380-1389. doi:10.15252/emmm.201606382
2015
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99. doi:10.1016/j.stem.2015.08.007
Dobreva G, Braun T. “The transcriptional landscape of regenerating newborn mouse hearts.” Circ Res 2015, 116(5):767-9. doi:10.1161/CIRCRESAHA
Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Yanchun G, Kühl S, Sinnecker D, Lipp P, Laugwitz KL, Kühl M, Moretti A. “Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity.” Stem Cells 2015, 33(4): 1113-1129. doi:10.1002/stem.1923
Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK. “Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex.” Cereb Cortex 2015, 25(10): 3406-19. doi:10.1093/cercor/bhu156
2014
Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19. doi:10.3389/fgene.2014.00019
2013
Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. “Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.” Circ Res 2013, 113(7):856-62. doi:10.1161/CIRCRESAHA.113.302035
2012
Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK. “A network of genetic repression and derepression specifies projection fates in the developing neocortex.” Proc Natl Acad Sci U S A 2012, 109(47):19071-8. doi:10.1073/pnas.1216793109