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2025
Acari A, Lodha P, Özhan S, Hemanna S, Rieck J, Drotleff B, Dieterich LC. A deep, quantitative lipid atlas of extracellular vesicles across multiple cell lines. bioRxiv [Preprint]. 2025 Aug 28:2025.08.22.671852
DOI: 10.1101/2025.08.22.671852
Centner FS, Brohm K, Mindt S, Jaeger E, Hahn B, Fuderer T, Lindner HA, Schneider-Lindner V, Krebs J, Neumaier M, Thiel M, Schoettler JJ. Evaluation of Hypoxia Markers in Critically Ill Patients Categorized by Their Burden of Organ Dysfunction: A Novel Approach to Detect Pathophysiological and Clinical Relevance in a Secondary Analysis of a Prospective Observational Study. Int J Mol Sci. 2025 Jan 14;26(2):659
DOI: 10.3390/ijms26020659
Polatoglou E, Bronkhorst A, Costina V, Gerhards C, Hedtke M, Holdenrieder S, Haselmann V. Comparison of purification protocols for effective large-primer removal between rounds of PCR amplification. Biotechniques. 2025 Nov-Dec;77(11-12):355-365
DOI: 10.1080/07366205.2025.2598186
2024
Hirschinger H, Jaeger E, Nittka S, Hetjens S, Lorenz C, Remi C, Saussele S, Hofmann WK, Gencer D, Boch T. Treatment of agitation in terminally ill patients with intranasal midazolam versus subcutaneous midazolam: study protocol for a randomised controlled open-label monocentric trial (MinTU Study). BMC Palliat Care. 2024 Jan 3;23(1):8
DOI: 10.1186/s12904-023-01330-1
Otto, M et al. Ein Mesh-Vernebler für alle? In-vitro-Evaluation der Medikamentenverneblung bei spontan atmenden, nicht invasiv und invasiv beatmeten prähospitalen Notfallpatient*innen. NOTARZT 2024; 40(03): 134 – 141.
Schoettler JJ et al. Mortality Prediction by Kinetic Parameters of Lactate and S-Adenosylhomocysteine in a Cohort of Critically Ill Patients. Int J Mol Sci. 2024 Jun 9;25(12):6391.
DOI: 10.3390/ijms25126391
Singin Ö et al. Analysis of the Mouse Hepatic Peroxisome Proteome—Identification of Novel Protein Constituents Using a Semi-Quantitative SWATH-MS Approach. Cells. 2024; 13(2):176.
2023
Centner FS et al. S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study. Int J Mol Sci. 24. 12600. 10.3390/ijms241612600.
Neumaier M, Giesler S, Ast V, Roemer M, Voß TD, Reinz E, Costina V, Schmelz M, Nürnberg E, Nittka S, Leppä AM, Rudolf R, Trumpp A, Fuchs T. Opsonization-independent antigen-specific recognition by myeloid phagocytes expressing monoclonal antibodies. Sci Adv. 2023 Sep;9(35):eadg1812
Otto M, Kropp Y, Jäger E, Neumaier M, Thiel M, Quintel M, Tsagogiorgas C. The Use of an Inspiration-Synchronized Vibrating Mesh Nebulizer for Prolonged Inhalative Iloprost Administration in Mechanically Ventilated Patients-An In Vitro Model. Pharmaceutics. 2023 Aug 3;15(8):2080.
DOI: 10.3390/pharmaceutics15082080
Xu Q et al. 5-Azacytidine in Combination with a novel pan-lysyl oxidase inhibitor synergistically restores erythropoiesis in myelodysplastic malignancies. Leukemia Research. 128. 107125. 10.1016/j.leukres.2023.107125.
DOI: 10.1038/s41467-023-37175-8
Xu Q et al. Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies. Nature Communications. 14. 10.1038/s41467-023-37175-8.
DOI: 10.1038/s41375-024-02181-2
2022
Filipović D, Costina V, Findeisen P, Inta D. Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats. Int J Mol Sci. 2022 Dec 5;23(23):1535
Hedtke M et al. Liquid profiling of circulating tumor DNA in colorectal cancer: steps needed to achieve its full clinical value as standard care. Molecular Oncology. 2022;16.10: 2042-2056
Hemberger J, Ittensohn J, Griffiths H, Keller M, Costina V, Albrecht S, Miethke T. The Promoter of the Immune-Modulating Gene TIR-Containing Protein C of the Uropathogenic Escherichia coli Strain CFT073 Reacts to the Pathogen's Environment. Int J Mol Sci. 2022 Jan 20;23(3):1148
DOI: 10.3390/ijms23031148
Xu Q, Streuer A, Jann JC, Altrock E, Schmitt N, Flach J, Sens-Albert C, Rapp F, Wolf J, Nowak V, Weimer N, Obländer J, Palme I, Kuzina M, Jawhar A, Darwich A, Weis CA, Marx A, Wuchter P, Costina V, Jäger E, Sperk E, Neumaier M, Fabarius A, Metzgeroth G, Nolte F, Steiner L, Levkin PA, Jawhar M, Hofmann WK, Riabov V, Nowak D. Inhibition of lysyl oxidases synergizes with 5-azacytidine to restore erythropoiesis in myelodysplastic and myeloid malignancies. Nat Commun. 2023 Mar 17;14(1):1497.
DOI: 10.1038/s41467-023-37175-8
2021
Kohl V, Drews O, Costina V, Bierbaum M, Jawhar A, Roehl H, Weiss C, Brendel S, Kleiner H, Flach J, Spiess B, Seifarth W, Nowak D, Hofmann WK, Fabarius A, Popp HD. Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells. Int J Mol Sci. 2021 May 29;22(11):5844.
doi: 10.3390/ijms22115844
Kohl V, Fabarius A, Drews O, Bierbaum M, Jawhar A, Darwich A, Weiss C, Flach J, Brendel S, Kleiner H, Seifarth W, Hofmann WK, Popp HD. Genotoxic Bystander Signals from Irradiated Human Mesenchymal Stromal Cells Mainly Localize in the 10-100 kDa Fraction of Conditioned Medium. Cells. 2021 Apr 7;10(4):827.
2020
Perić I, Costina V, Gass P, Findeisen P, Filipović D.Hippocampal synaptoproteomic changes of susceptibility and resilience of male rats to chronic social isolation. Brain Res Bull. 2021 Jan;166:128-141.
doi: 10.1016/j.brainresbull.2020.11.013
Haselmann V et al., Results of the first pilot external quality assessment (EQA) scheme for anti-SARS-CoV2-antibody testing. Clin Chem Lab Med. 2020 Aug 27
doi:10.1515/cclm-2020-1183
Filipović D et al., Social isolation stress-resilient rats reveal energy shift from glycolysis to oxidative phosphorylation in hippocampal nonsynaptic mitochondria. Life Sci. 2020 Aug 1;254:117790.
doi:10.1016/j.lfs.2020.117790
Haselmann V et al., Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples. Clin Chim Acta. 2020 Jul 9;510:73-78.
Mindt S et al., Mass spectrometry-based method for quantification of nimodipine and glutamate in cerebrospinal fluid. Pilot study with patients after aneurysmal subarachnoid haemorrhage. J Clin Pharm Ther. 2020 Feb;45(1):81-87.
2019
Abu Sammour D et al., Quantitative Mass Spectrometry Imaging Reveals Mutation Status-independent Lack of Imatinib in Liver Metastases of Gastrointestinal Stromal Tumors. Sci Rep. 2019 Jul 23;9(1):10698.
doi: 10.1038/s41598-019-47089-5
Findeisen P, Hemanna S, Maharjan RS, Mindt S, Costina V, Hofheinz R, Neumaier M. Mass spectrometry based analytical quality assessment of serum and plasma specimens with patterns of endo- and exogenous peptides. Clin Chem Lab Med. 2019 Apr 24;57(5):668-678.
doi.org/10.1515/cclm-2018-0811
Fuchs T, Puellmann K, Dreyfus DH, Piehler AP, Reuter B, Schwarzbach C, Willmann O, Yepes D, Costina V, Findeisen P, Mahrt J, Wang C, Han J, Beham AW, Neumaier M, Kaminski WE. Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis. Front Neurol. 2019 Apr 2;10:307.
doi.org/10.3389/fneur.2019.00307
Kittel M, Findeisen P, Ghebremedhin B, Miethke T, Grundt A, Ahmad-Nejad P, Neumaier M. Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring. Clin Chem Lab Med. 2019 Jul 26;57(8):1271-1279.
doi.org/10.1515/cclm-2018-1178
Kittel M, Findeisen P, Ghebremedhin B, Miethke T, Grundt A, Ahmad-Nejad P, Neumaier M. Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring. Clin Chem Lab Med. 2019 Jul 26;57(8):1271-1279.
doi.org/10.1515/cclm-2018-1178
Erich K, Reinle K, Müller T, Munteanu B, Sammour DA, Hinsenkamp I, Gutting T, Burgermeister E, Findeisen P, Ebert MP, Krijgsveld J, Hopf C. Spatial Distribution of Endogenous Tissue Protease Activity in Gastric Carcinoma Mapped by MALDI Mass Spectrometry Imaging. Mol Cell Proteomics. 2019 Jan;18(1):151-161
doi.org/10.1074/mcp.RA118.000980
Mindt S, Aida S, Merx K, Müller A, Gutting T, Hedtke M, Neumaier M, Hofheinz RD. Therapeutic drug monitoring (TDM) of 5-fluorouracil (5-FU): new preanalytic aspects. Clin Chem Lab Med. 2019 Jan 30.
doi.org/10.1515/cclm-2018-1177
Mindt S, Andrade-Barazarte H, Tokhi U, Ludtka C, Neumaier M, Hänggi D. Immunoluminometric assay for copeptin measurement in cerebrospinal fluid: Technical aspects and pilot study. Clin Chim Acta. 2019 Mar;490:181-185.
doi.org/10.1016/j.cca.2018.09.005
2018
Findeisen P, Hemanna S, Maharjan RS, Mindt S, Costina V, Hofheinz R, Neumaier M. Mass spectrometry based analytical quality assessment of serum and plasma specimens with patterns of endo- and exogenous peptides. Clin Chem Lab Med. 2019 Apr 24;57(5):668-678.
doi.org/10.1515/cclm-2018-0811
Kittel M, Greulich A, Findeisen P, Haselmann V, Burrer A, Willem C, Miethke T, Ahmad-Nejad P, Neumaier M. Direct MS-Based Bacterial Identification of Blood Cultures. Comparison of an In-House TritonX-Protocol with Bruker-Sepsityper? Clin Lab. 2018 Oct 31;64(11).
doi.org/10.7754/clin.lab.2018.180522
Perić I, Costina V, Stanisavljević A, Findeisen P, Filipović D. Proteomic characterization of hippocampus of chronically socially isolated rats treated with fluoxetine: Depression-like behaviour and fluoxetine mechanism of action. Neuropharmacology. 2018 Jun;135:268-283
doi.org/10.1016/j.neuropharm.2018.03.034
Mindt S, Karampinis I, John M, Neumaier M, Nowak K. Stability and degradation of indocyanine green in plasma, aqueous solution and whole blood. Photochem Photobiol Sci. 2018 Sep 12;17(9):1189-1196.
Mindt S, Karampinis I, John M, Neumaier M, Nowak K. Stability and degradation of indocyanine green in plasma, aqueous solution and whole blood. Photochem Photobiol Sci. 2018 Sep 12;17(9):1189-1196.
2017
Koudelkova P, Costina V, Weber G, Dooley S, Findeisen P, Winter P, Agarwal R, Schlangen K, Mikulits W. Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells. Int J Mol Sci. 2017 Oct 10;18(10).
Filipović D, Costina V, Perić I, Stanisavljević A, Findeisen P. Chronic fluoxetine treatment directs energy metabolism towards the citric acid cycle and oxidative phosphorylation in rat hippocampal nonsynaptic mitochondria. Brain Res. 2017 Mar 15;1659:41-54.
doi.org/10.1016/j.brainres.2017.01.025
Dozio E, Di Gaetano N, Findeisen P, Corsi Romanelli MM. Glycated albumin: from biochemistry and laboratory medicine to clinical practice. Endocrine. 2017 Mar;55(3):682-690.
doi.org/10.1007/s12020-016-1091-6
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, Manner A, Islinger M, Schrader M. ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. J Cell Biol. 2017 Feb;216(2):331-342.