CBTM Open Seminar: Escape the Rodent Trap
Montag, 01.07.2019, 13:30
Ort: Tridomus B, S43, Ludolf-Krehl-Straße 13-17, 68167 Mannheim
Escape the rodent trap: using iPS-cell derived neurons for pain research
A major challenge in human pain research is the translational gap – findings from mice are not easily translated to humans. Therefore, we established a human induced stem cell (iPS-cell) based approach to differentiate nociceptors of patients with genetic pain syndromes. This system allows us to study the role of voltage gated sodium channels, e.g. Nav1.7, in action potential firing. Ultimately, our goal is to identify personalized medicine for individual, treatment-resistant patients using iPSC derived human nociceptors. We report an example of in-vitro predicted individualized treatment success in a Caucasian patient suffering from severe small fiber neuropathy (SFN) with a genetic variant in Nav1.9. Thus, this stem-cell based approach ended a history of 10-years of severe pain for the patient.
Prof. Angelika LampertInstitute of Physiology, UK Aachen